{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:36Z","timestamp":1791406956847,"version":"4.3.3"},"reference-count":112,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Hypoxic pulmonary vasoconstriction (HPV) is a mechanism by which pulmonary arteries maintain blood oxygenation during alveolar hypoxia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>HPV is generally studied using a vasoconstricting co\u2010stimulus that amplifies the HPV but may also distort its properties; we therefore characterised HPV in isolated rat intrapulmonary arteries during 40 min hypoxic challenges in the absence of any such stimulus.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Immediate (phase 1) and sustained (phase 2) components of HPV were unaffected by blocking voltage\u2010gated Ca<jats:sup>2+<\/jats:sup> channels but were abolished by depletion of sarcoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>. Phase 2 was attenuated by blockade of store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry (SOCE), although it largely persisted in Ca<jats:sup>2+<\/jats:sup>\u2010free physiological saline solution.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>HPV was associated with an increase in the intrapulmonary artery ratio of oxidised to reduced glutathione and was inhibited by antioxidants.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>HPV resulted primarily from intracellular Ca<jats:sup>2+<\/jats:sup> release, with SOCE making a contribution, particularly to phase 2. Sustained HPV involves oxidation of the pulmonary artery redox state.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p><jats:bold>Abstract\u2002<\/jats:bold> Hypoxic pulmonary vasoconstriction (HPV) maintains blood oxygenation during acute hypoxia but contributes to pulmonary hypertension during chronic hypoxia. The mechanisms of HPV remain controversial, in part because HPV is usually studied in the presence of agonist\u2010induced preconstriction (\u2018pretone\u2019). This potentiates HPV but may obscure and distort its underlying mechanisms. We therefore carried out an extensive assessment of proposed mechanisms contributing to HPV in isolated intrapulmonary arteries (IPAs) in the absence of pretone by using a conventional small vessel myograph. Hypoxia elicited a biphasic constriction consisting of a small transient (phase 1) superimposed upon a sustained (phase 2) component. Neither phase was affected by the L\u2010type Ca<jats:sup>2+<\/jats:sup> channel antagonists diltiazem (10 and 30 \u03bc<jats:sc>m<\/jats:sc>) or nifedipine (3 \u03bc<jats:sc>m<\/jats:sc>). Application of the store\u2010operated Ca<jats:sup>2+<\/jats:sup> entry (SOCE) blockers BTP2 (10 \u03bc<jats:sc>m<\/jats:sc>) or SKF96365 (50 \u03bc<jats:sc>m<\/jats:sc>) attenuated phase 2 but not phase 1, whereas a lengthy (30 min) incubation in Ca<jats:sup>2+<\/jats:sup>\u2010free physiological saline solution similarly reduced phase 2 but abolished phase 1. No further effect of inhibition of HPV was observed if the sarco\/endoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase inhibitor cyclopiazonic acid (30 \u03bc<jats:sc>m<\/jats:sc>) was also applied during the 30 min incubation in Ca<jats:sup>2+<\/jats:sup>\u2010free physiological saline solution. Pretreatment with 10 \u03bc<jats:sc>m<\/jats:sc> ryanodine and 15 m<jats:sc>m<\/jats:sc> caffeine abolished both phases, whereas treatment with 100 \u03bc<jats:sc>m<\/jats:sc> ryanodine attenuated both phases. The two\u2010pore channel blocker NED\u201019 (1 \u03bc<jats:sc>m<\/jats:sc>) and the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist BZ194 (200 \u03bc<jats:sc>m<\/jats:sc>) had no effect on either phase of HPV. The lysosomal Ca<jats:sup>2+<\/jats:sup>\u2010depleting agent concanamycin (1 \u03bc<jats:sc>m<\/jats:sc>) enhanced HPV if applied during hypoxia, but had no effect on HPV during a subsequent hypoxic challenge. The cyclic ADP ribose antagonist 8\u2010bromo\u2010cyclic ADP ribose (30 \u03bc<jats:sc>m<\/jats:sc>) had no effect on either phase of HPV. Neither the Ca<jats:sup>2+<\/jats:sup>\u2010sensing receptor (CaSR) blocker NPS2390 (0.1 and 10 \u03bc<jats:sc>m<\/jats:sc>) nor FK506 (10 \u03bc<jats:sc>m<\/jats:sc>), a drug which displaces FKBP12.6 from ryanodine receptor 2 (RyR2), had any effect on HPV. HPV was virtually abolished by the rho kinase blocker Y\u201027632 (1 \u03bc<jats:sc>m<\/jats:sc>) and attenuated by the protein kinase C inhibitor G\u00f66983 (3 \u03bc<jats:sc>m<\/jats:sc>). Hypoxia for 45 min caused a significant increase in the ratio of oxidised to reduced glutathione (GSSG\/GSH). HPV was unaffected by the NADPH oxidase inhibitor VAS2870 (10 \u03bc<jats:sc>m<\/jats:sc>), whereas phase 2 was inhibited but phase 1 was unaffected by the antioxidants ebselen (100 \u03bc<jats:sc>m<\/jats:sc>) and TEMPOL (3 m<jats:sc>m<\/jats:sc>). We conclude that both phases of HPV in this model are mainly dependent on [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> release from the sarcoplasmic reticulum. Neither phase of HPV requires voltage\u2010gated Ca<jats:sup>2+<\/jats:sup> entry, but SOCE contributes to phase 2. We can detect no requirement for cyclic ADP ribose, NAADP\u2010dependent lysosomal Ca<jats:sup>2+<\/jats:sup> release, activation of the CaSR, or displacement of FKBP12.6 from RyR2 for either phase of HPV. Sustained HPV is associated with an oxidising shift in the GSSG\/GSH redox potential and is inhibited by the antioxidants ebselen and TEMPOL, consistent with the concept that it requires an oxidising shift in the cell redox state or the generation of reactive oxygen species.<\/jats:p>","DOI":"10.1113\/jphysiol.2013.253682","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T03:05:48Z","timestamp":1371524748000},"page":"4473-4498","source":"Crossref","is-referenced-by-count":44,"title":["Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca<sup>2+<\/sup> release"],"prefix":"10.1113","volume":"591","author":[{"given":"Michelle J.","family":"Connolly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Prieto\u2010Lloret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P. T.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip I.","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015812"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.098855"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.165837"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1010-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.1.174"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000137173.42723.fb"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L888"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"A1229","DOI":"10.1096\/fasebj.20.5.A1229-c","article-title":"Influence of pretone agents on Ca2+ release and influx pathways during HPV","volume":"20","author":"Becker S","year":"2006","journal-title":"FASEB J"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470035009.ch19"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198303000-00003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204891200"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000047507.22487.85"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195309"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08030"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581262"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.101485"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1378.053"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn349"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"L469","DOI":"10.1152\/ajplung.1994.266.4.L469","article-title":"Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells","volume":"266","author":"Cornfield DN","year":"1994","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809997106"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2862"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.093616"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.2.L318"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(02)00213-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033514"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-500-2_4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(02)00046-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510040200"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701295"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(04)81003-6"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90139-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.4_Supplement.233S"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2011.06.005"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201004152"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411797200"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1886"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.6.2468"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.024067"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701326"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.03.011"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.09.030"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406132200"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2007.11.003"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn209"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2005.56"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.1"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00211.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"crossref","first-page":"L223","DOI":"10.1152\/ajplung.1994.266.3.L223","article-title":"Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries","volume":"266","author":"Leach RM","year":"1994","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0556-8"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3047"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L856"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.276.5.L805"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00063.2009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.2.375"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.38.2.99"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.04.003"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106241"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110949"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2002.92.2.527"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00733.2004"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05124-11"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.4.404"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00258.2007"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00065.2012"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.078311"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000219677.12988.e9"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.4.C882"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.08.020"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.06.012"},{"key":"e_1_2_6_71_1","doi-asserted-by":"crossref","first-page":"H301","DOI":"10.1152\/ajpheart.1995.268.1.H301","article-title":"Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: evidence for PKC\u2010independent Ca2+ sensitization","volume":"268","author":"Robertson TP","year":"1995","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703537"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00669.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.07.035"},{"key":"e_1_2_6_75_1","first-page":"952","article-title":"Hypoxic contraction of isolated rat pulmonary artery","volume":"248","author":"Rodman DM","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.2.C323"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.3.L434"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00480-4"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.5.L1115"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.07.192"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00656-6"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.101394"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2003"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.052"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2010"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00903.2004"},{"key":"e_1_2_6_87_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.33549\/physiolres.931875","article-title":"A role for receptor\u2010operated Ca2+ entry in human pulmonary artery smooth muscle cells in response to hypoxia","volume":"59","author":"Tang C","year":"2010","journal-title":"Physiol Res"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.01.022"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00179.2004"},{"key":"e_1_2_6_90_1","doi-asserted-by":"crossref","first-page":"L591","DOI":"10.1152\/ajplung.1993.265.6.L591","article-title":"Effect of hypoxia and norepinephrine on cytoplasmic free Ca2+ in pulmonary and cerebral arterial myocytes","volume":"265","author":"Vadula MS","year":"1993","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0859com"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00348.2011"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00448.2004"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00141.2007"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59176"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.02.006"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.06.026"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1201.091960"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.206334"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00044.2005"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.2.7781921"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2003.10.003"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606728103"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)00133-K"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.276.1.L90"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0337OC"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004849200"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1107-1"},{"key":"e_1_2_6_109_1","doi-asserted-by":"crossref","first-page":"H281","DOI":"10.1152\/ajpheart.1990.259.2.H281","article-title":"Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries","volume":"259","author":"Yuan XJ","year":"1990","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_6_110_1","doi-asserted-by":"crossref","first-page":"L52","DOI":"10.1152\/ajplung.1994.267.1.L52","article-title":"Deoxyglucose and reduced glutathione mimic effects of hypoxia on K+ and Ca2+ conductances in pulmonary artery cells","volume":"267","author":"Yuan XJ","year":"1994","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4168"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2003.09.006"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409232"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2013.253682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2013.253682","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2013.253682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T22:06:16Z","timestamp":1698530776000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2013.253682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":112,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1113\/jphysiol.2013.253682"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2013.253682","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,9]]}}}