{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:45Z","timestamp":1790487645909,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>Control of regional cardiac function, as mediated by the intrinsic cardiac (IC) nervous system, is dependent upon its cardiac afferent neuronal inputs, changes in its central neuronal drive and interactions mediated within via local circuit neurons.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The majority of its local circuit neurons receive indirect central (sympathetic and parasympathetic) inputs, lesser proportions transducing the cardiac milieu.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Fifty per cent of IC neurons exhibit cardiac cycle\u2010related periodicity that is primarily related to direct cardiac mechano\u2010sensory afferent inputs and, secondarily, to indirect central autonomic efferent inputs.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In response to mediastinal nerve stimulation, most IC neurons became excessively activated in the induction of atrial arrhythmias such that their stochastic interactivity precedes and persists throughout neuronally induced atrial fibrillation.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Modulation of such stochastic IC local circuit neuronal recruitment may represent a novel target for the treatment of select cardiac disease, including atrial arrhythmias.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:bold>Abstract\u2002<\/jats:bold>The aims of the study were to determine how aggregates of intrinsic cardiac (IC) neurons transduce the cardiovascular milieu<jats:italic>versus<\/jats:italic>responding to changes in central neuronal drive and to determine IC network interactions subsequent to induced neural imbalances in the genesis of atrial fibrillation (AF). Activity from multiple IC neurons in the right atrial ganglionated plexus was recorded in eight anaesthetized canines using a 16\u2010channel linear microelectrode array. Induced changes in IC neuronal activity were evaluated in response to: (1) focal cardiac mechanical distortion; (2) electrical activation of cervical vagi or stellate ganglia; (3) occlusion of the inferior vena cava or thoracic aorta; (4) transient ventricular ischaemia, and (5) neurally induced AF. Low level activity (ranging from 0 to 2.7 Hz) generated by 92 neurons was identified in basal states, activities that displayed functional interconnectivity. The majority (56%) of IC neurons so identified received indirect central inputs (vagus alone: 25%; stellate ganglion alone: 27%; both: 48%). Fifty per cent transduced the cardiac milieu responding to multimodal stressors applied to the great vessels or heart. Fifty per cent of IC neurons exhibited cardiac cycle periodicity, with activity occurring primarily in late diastole into isovolumetric contraction. Cardiac\u2010related activity in IC neurons was primarily related to direct cardiac mechano\u2010sensory inputs and indirect autonomic efferent inputs. In response to mediastinal nerve stimulation, most IC neurons became excessively activated; such network behaviour preceded and persisted throughout AF. It was concluded that stochastic interactions occur among IC local circuit neuronal populations in the control of regional cardiac function. Modulation of IC local circuit neuronal recruitment may represent a novel approach for the treatment of cardiac disease, including atrial arrhythmias.<\/jats:p>","DOI":"10.1113\/jphysiol.2013.259382","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:58:35Z","timestamp":1372726715000},"page":"4515-4533","source":"Crossref","is-referenced-by-count":127,"title":["Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function"],"prefix":"10.1113","volume":"591","author":[{"given":"Eric","family":"Beaumont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Salavatian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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