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A considerable body of evidence indicates that the primary event initiating the disease process is the excessive release of Ca<jats:sup>2+<\/jats:sup> from intracellular stores, followed by excessive entry of Ca<jats:sup>2+<\/jats:sup> from the interstitial fluid. However, Ca<jats:sup>2+<\/jats:sup> release and subsequent entry are also precisely the processes that control the physiological secretion of digestive enzymes in response to stimulation via the vagal nerve or the hormone cholecystokinin. The spatial and temporal Ca<jats:sup>2+<\/jats:sup> signal patterns in physiology and pathology, as well as the contributions from different organelles in the different situations, are therefore critical issues. There has recently been significant progress in our understanding of both physiological stimulus\u2013secretion coupling and the pathophysiology of acute pancreatitis. Very recently, a promising potential therapeutic development has occurred with the demonstration that the blockade of Ca<jats:sup>2+<\/jats:sup> release\u2010activated Ca<jats:sup>2+<\/jats:sup> currents in pancreatic acinar cells offers remarkable protection against Ca<jats:sup>2+<\/jats:sup> overload, intracellular protease activation and necrosis evoked by a combination of alcohol and fatty acids, which is a major trigger of acute pancreatitis.<\/jats:p>","DOI":"10.1113\/jphysiol.2013.261784","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T01:47:16Z","timestamp":1375148836000},"page":"269-280","source":"Crossref","is-referenced-by-count":144,"title":["The role of Ca<sup>2+<\/sup> in the pathophysiology of pancreatitis"],"prefix":"10.1113","volume":"592","author":[{"given":"Julia V.","family":"Gerasimenko","sequence":"first","affiliation":[{"name":"MRC Group Cardiff School of Biosciences, Cardiff University  Cardiff 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