{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:10:27Z","timestamp":1791195027814,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Heart, Lung and Blood Institute of NIH","award":["PO1-HL62222"],"award-info":[{"award-number":["PO1-HL62222"]}]},{"name":"American Heart Association, Midwest Affiliate","award":["11POST5050000"],"award-info":[{"award-number":["11POST5050000"]}]},{"name":"Coridea Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A strong correlation between disordered breathing patterns, elevated sympathetic nerve activity and enhanced chemoreflex sensitivity exists in patients with heart failure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Evidence indicates that disordered breathing patterns and increased sympathetic nerve activity increases arrhythmia incidence in patients with heart failure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Enhanced coupling between sympathetic and respiratory neural drive underlies elevated sympathetic nerve activity in an animal model of sleep apnoea.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We investigated the impact of carotid body chemoreceptor denervation on sympathetic nerve activity, disordered breathing and sympatho\u2010respiratory coupling in an animal model of heart failure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Renal sympathetic nerve activity, apnoea\/hypopnoea incidence, variability measures of tidal volume and respiratory rate and arrhythmia incidence were quantified during resting breathing in heart failure animals with and without carotid body ablation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our results indicate that carotid body chemoreceptor denervation reduces sympathetic nerve activity, disordered breathing patterns, arrhythmia incidence and sympatho\u2010respiratory coupling in experimental heart failure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings suggest that device\u2010oriented ablation of carotid body chemoreceptors is a viable treatment option for reduction of sympathetic nerve activity, disordered breathing patterns and arrhythmia incidence in heart failure.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      In congestive heart failure (CHF), carotid body (CB) chemoreceptor activity is enhanced and is associated with oscillatory (Cheyne\u2013Stokes) breathing patterns, increased sympathetic nerve activity (SNA) and increased arrhythmia incidence. We hypothesized that denervation of the CB (CBD) chemoreceptors would reduce SNA, reduce apnoea and arrhythmia incidence and improve ventricular function in pacing\u2010induced CHF rabbits. Resting breathing, renal SNA (RSNA) and arrhythmia incidence were measured in three groups of animals: (1) sham CHF\/sham\u2013CBD (sham\u2013sham); (2) CHF\/sham\u2013CBD (CHF\u2013sham); and (3) CHF\/CBD (CHF\u2013CBD). Chemoreflex sensitivity was measured as the RSNA and minute ventilatory (\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp5992-math-0001.png\" xlink:title=\"urn:x-wiley:00223751:tjp5992:equation:tjp5992-math-0001\"\/>\n                      ) responses to hypoxia and hypercapnia. Respiratory pattern was measured by plethysmography and quantified by an apnoea\u2013hypopnoea index, respiratory rate variability index and the coefficient of variation of tidal volume. Sympatho\u2010respiratory coupling (SRC) was assessed using power spectral analysis and the magnitude of the peak coherence function between tidal volume and RSNA frequency spectra. Arrhythmia incidence and low frequency\/high frequency ratio of heart rate variability were assessed using ECG and blood pressure waveforms, respectively. RSNA and\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tjp5992-math-0002.png\" xlink:title=\"urn:x-wiley:00223751:tjp5992:equation:tjp5992-math-0002\"\/>\n                      responses to hypoxia were augmented in CHF\u2013sham and abolished in CHF\u2013CBD animals. Resting RSNA was greater in CHF\u2013sham compared to sham\u2013sham animals (43\u00a0\u00b1\u00a05% max\n                      <jats:italic>vs<\/jats:italic>\n                      . 23 \u00b1 2% max,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and this increase was not found in CHF\u2013CBD animals (25\u00a0\u00b1\u00a01% max,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05\n                      <jats:italic>vs<\/jats:italic>\n                      . CHF\u2013sham). Low frequency\/high frequency heart rate variability ratio was similarly increased in CHF and reduced by CBD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Respiratory rate variability index, coefficient of variation of tidal volume and apnoea\u2013hypopnoea index were increased in CHF\u2013sham animals and reduced in CHF\u2013CBD animals (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). SRC (peak coherence) was increased in CHF\u2013sham animals (sham\u2013sham 0.49\u00a0\u00b1\u00a00.05; CHF\u2013sham 0.79\u00a0\u00b1\u00a00.06), and was attenuated in CHF\u2013CBD animals (0.59\u00a0\u00b1\u00a00.05) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 for all comparisons). Arrhythmia incidence was increased in CHF\u2013sham and reduced in CHF\u2013CBD animals (213\u00a0\u00b1\u00a058 events\u00a0h\n                      <jats:sup>\u20131<\/jats:sup>\n                      CHF, 108\u00a0\u00b1\u00a048 events\u00a0h\n                      <jats:sup>\u20131<\/jats:sup>\n                      CHF\u2013CBD,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Furthermore, ventricular systolic (3.8\u00a0\u00b1\u00a00.7\n                      <jats:italic>vs<\/jats:italic>\n                      . 6.3\u00a0\u00b1\u00a00.5\u00a0ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and diastolic (6.3\u00a0\u00b1\u00a01.0\n                      <jats:italic>vs<\/jats:italic>\n                      . 9.1\u00a0\u00b1\u00a00.5\u00a0ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) volumes were reduced, and ejection fraction preserved (41\u00a0\u00b1\u00a05%\n                      <jats:italic>vs<\/jats:italic>\n                      . 54\u00a0\u00b1\u00a02% reduction from pre\u2010pace,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) in CHF\u2013CBD compared to CHF\u2013sham rabbits. Similar patterns of changes were observed longitudinally within the CHF\u2013CBD group before and after CBD. In conclusion, CBD is effective in reducing RSNA, SRC and arrhythmia incidence, while improving breathing stability and cardiac function in pacing\u2010induced CHF rabbits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jphysiol.2013.266221","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:46:38Z","timestamp":1384818398000},"page":"391-408","source":"Crossref","is-referenced-by-count":152,"title":["Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure"],"prefix":"10.1113","volume":"592","author":[{"given":"Noah J.","family":"Marcus","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Nebraska Medical Center  Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Department of Cellular 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