{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:33Z","timestamp":1787016273143,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["209113"],"award-info":[{"award-number":["209113"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heart and Stroke Foundation of Ontario","award":["T-6624"],"award-info":[{"award-number":["T-6624"]}]},{"name":"Canadian Foundation for Innovation","award":["23100"],"award-info":[{"award-number":["23100"]}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ontario Graduate Scholarship in Science and Technology"},{"name":"Heart and Stroke Foundation of Canada."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2014,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Suboptimal intrauterine conditions and consequent intrauterine growth reduction (IUGR), resulting in low birth weight (LBW), increase the risk for hypertension and cardiovascular disease in adulthood.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LBW offspring who experience an accelerated growth in childhood have a higher risk of cardiovascular disease than those who grow more slowly, suggesting that the postnatal environment interacts with programmed deficits in organ function to influence disease risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We show here that arterial stiffening in LBW guinea pig offspring is exacerbated with postnatal feeding of a Western diet, suggesting that IUGR confers heightened vascular susceptibility to postnatal risk factors and thus may contribute to an individual's total risk score.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our results also demonstrate that the independent effect of the intrauterine environment on vascular function in young adult guinea pigs is greater than the effect of a postnatal Western diet, thus highlighting the importance of prenatal factors on long\u2010term vascular health.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      The association between intrauterine growth restriction (IUGR) and hypertension is well established, yet the interaction between IUGR and other pathogenic contributors remains ill\u2010defined. This study examined the independent and interactive effects of fetal growth reduction resulting in low birth weight (LBW), and postnatal Western diet (WD) on vascular function. Growth reduction was induced in pregnant guinea pigs by uterine artery ablation. LBW and normal birth weight (NBW) offspring were randomly assigned to a control diet (CD) or a WD. In young adulthood, length\u2013tension curves were generated in aortic rings and responses to methacholine (MCh) were evaluated in the carotid and aorta using wire myography. Relative to NBW\/CD, aortae of NBW\/WD offspring were stiffer, as determined by a leftward shift in the length\u2013tension curve, yet the shift in the LBW\/CD curve was considerably greater. Aortic stiffening was most severe in LBW\/WD (slope: NBW\/CD, 1.97\u00a0\u00b1\u00a00.04; NBW\/WD, 2.16\u00a0\u00b1\u00a00.04; LBW\/CD, 2.28\u00a0\u00b1\u00a00.05; LBW\/WD, 2.34\u00a0\u00b1\u00a00.07). Maximal responses (\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) to MCh were significantly blunted in the aorta of LBW\/CD\n                      <jats:italic>vs<\/jats:italic>\n                      . NBW\/CD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and in LBW\/WD\n                      <jats:italic>vs<\/jats:italic>\n                      . NBW\/WD offspring (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05); but WD alone had no influence on MCh responses.\n                      <jats:italic>E<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      values for carotid responses to MCh were reduced in LBW\/CD\n                      <jats:italic>vs<\/jats:italic>\n                      . NBW\/CD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Thus, aortic stiffening was influenced more by LBW than by a postnatal WD and the most severe stiffening was observed in LBW\/WD offspring. In contrast, blunted endothelial responses in LBW\/CD offspring were not exacerbated by WD. IUGR may have a greater independent impact on vascular function than a postnatal WD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jphysiol.2014.275016","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T06:18:15Z","timestamp":1414736295000},"page":"5429-5443","source":"Crossref","is-referenced-by-count":25,"title":["Low birth weight followed by postnatal over\u2010nutrition in the guinea pig exposes a predominant player in the development of vascular dysfunction"],"prefix":"10.1113","volume":"592","author":[{"given":"Jennifer A.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology The University of Western London  Ontario Canada"},{"name":"Department of Obstetrics and Gynaecology The University of Western London  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousseynou","family":"Sarr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The University of Western London  Ontario Canada"},{"name":"Lawson Health Research Institute The University of Western London  Ontario Canada"},{"name":"Children's Health Research Institute The University of Western London  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Piorkowska","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology The University of Western London  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gros","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology The University of Western London  Ontario Canada"},{"name":"Robarts Research Institute The University of Western London  Ontario Canada"},{"name":"Department of Medicine The University of Western London  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R. H.","family":"Regnault","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology The University of Western London  Ontario Canada"},{"name":"Department of Obstetrics and Gynaecology The University of Western London  Ontario Canada"},{"name":"Lawson Health Research Institute The University of Western London  Ontario Canada"},{"name":"Children's Health Research Institute The University of Western London  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f55038"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000053448.95913.3D"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.259"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2008.12.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00004.2001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.002816"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.121160"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00227.2006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000239294.17636.27"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02154-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27547"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3246"},{"key":"e_1_2_6_17_1","first-page":"153","article-title":"The blood supply to the heart and brain in the growth restricted guinea pig fetus","volume":"15","author":"Detmer A","year":"1991","journal-title":"J Dev Physiol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7181.427"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2927"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199606000-00023"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/intjepid\/31.2.294"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031017"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01802.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01232.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.38"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00407.2006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511001528"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014907"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.10503"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.6.R1675"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00587.2001"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00074-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.252239"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/1745039X.2012.710084"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.122200"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209509028396"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.187849"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.02.005"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1344"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00798.2006"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00641.2009"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.192955"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X07083392"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1992.tb09356.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/420979"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115204"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.391"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.210625"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00274.2011"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.11.023"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12155"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283596834"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01744"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00011"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4917fje"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1046"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000151373.33830.41"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00798.2005"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2014.275016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2014.275016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2014.275016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/jphysiol.2014.275016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2014.275016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:44:36Z","timestamp":1694295876000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2014.275016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":59,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,12,15]]}},"alternative-id":["10.1113\/jphysiol.2014.275016"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2014.275016","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}