{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:40:44Z","timestamp":1790718044004,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2014,11,15]]},"abstract":"<jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Medial geniculate body (MGB) single units recorded from sound\u2010exposed animals with behavioural evidence of tinnitus exhibits enhanced spontaneous firing and burst properties.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MGB units in tinnitus animals exhibit increased rate\u2010level function slope when driven by broadband noise and tones at the unit's characteristic frequency.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Elevated patterns of neuronal activity and altered bursting showed a significant positive correlation with animals\u2019 tinnitus scores.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Tinnitus is an auditory percept without an environmental acoustic correlate. Contemporary tinnitus models hypothesize tinnitus to be a consequence of maladaptive plasticity\u2010induced disturbance of excitation\u2013inhibition homeostasis, possibly convergent on medial geniculate body (MGB, auditory thalamus) and related neuronal networks. The MGB is an obligate acoustic relay in a unique position to gate auditory signals to higher\u2010order auditory and limbic centres. Tinnitus\u2010related maladaptive plastic changes of MGB\u2010related neuronal networks may affect the gating function of MGB and enhance gain in central auditory and non\u2010auditory neuronal networks, resulting in tinnitus. The present study examined the discharge properties of MGB neurons in the sound\u2010exposure gap inhibition animal model of tinnitus. MGB single unit responses were obtained from awake unexposed controls and sound\u2010exposed adult rats with behavioural evidence of tinnitus. MGB units in animals with tinnitus exhibited enhanced spontaneous firing, altered burst properties and increased rate\u2010level function slope when driven by broadband noise and tones at the unit's characteristic frequency. Elevated patterns of neuronal activity and altered bursting showed a significant positive correlation with animals\u2019 tinnitus scores. Altered activity of MGB neurons revealed additional features of auditory system plasticity associated with tinnitus, which may provide a testable assay for future therapeutic and diagnostic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1113\/jphysiol.2014.278572","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T06:11:07Z","timestamp":1410502267000},"page":"5065-5078","source":"Crossref","is-referenced-by-count":146,"title":["Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus"],"prefix":"10.1113","volume":"592","author":[{"given":"Bopanna I.","family":"Kalappa","sequence":"first","affiliation":[{"name":"Southern Illinois University School of Medicine Department of Pharmacology  Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Brozoski","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine Department of Surgery Division of Otolaryngology  Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy G.","family":"Turner","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine Department of Surgery Division of Otolaryngology  Springfield IL USA"},{"name":"Department of Psychology\u2010Illinois College  Jacksonville IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Caspary","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine Department of Pharmacology  Springfield IL USA"},{"name":"Southern Illinois University School of Medicine Department of Surgery Division of Otolaryngology  Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03005368909077819"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)00199-Z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.03.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.5.1999"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00593.2006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00238.2010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70237-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21699"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5100-06.2007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2451-05.2005"},{"key":"e_1_2_6_14_1","first-page":"37","article-title":"Health and Nutrition Examination Survey of 1971\u201375: Part II. 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