{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:44:28Z","timestamp":1790959468831,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["AR061987 (GP)"],"award-info":[{"award-number":["AR061987 (GP)"]}]},{"name":"National Institute of Health","award":["DC005017 (AS)"],"award-info":[{"award-number":["DC005017 (AS)"]}]},{"name":"National Institute of Health","award":["DC012225 (MR)"],"award-info":[{"award-number":["DC012225 (MR)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Key points<\/jats:title><jats:sec><jats:label\/><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Millions of elderly individuals have dysphagia, a debilitating and life\u2010threatening condition in which the ability to swallow is impaired.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Several muscles surround the three regions of the pharynx, which are essential for proper swallowing, yet the effects of ageing and disease on these muscles are not well understood.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We demonstrate that the fibre size of murine pharyngeal muscles is differentially affected by ageing and muscular dystrophy depending on their location within the pharynx.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Using a mouse model of an age\u2010associated dysphagic disease (oculopharyngeal muscular dystrophy), we show that overexpression of wild\u2010type polyadenylate binding nuclear protein\u00a01 in muscle tissue prevents age\u2010related dysphagia and age\u2010related muscle atrophy of laryngopharyngeal muscles.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results demonstrate that mice are an excellent model for studying mechanisms of ageing and disease on pharyngeal muscle physiology, and such studies could lead to new therapies for individuals with dysphagia.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The inability to swallow, or dysphagia, is a debilitating and life\u2010threatening condition that arises with ageing or disease. Dysphagia results from neurological or muscular impairment of one or more pharyngeal muscles, which function together to ensure proper swallowing and prevent the aspiration of food or liquid into the lungs. Little is known about the effects of age or disease on pharyngeal muscles as a group. Here we show ageing affected pharyngeal muscle growth and atrophy in wild\u2010type mice depending on the particular muscle analysed. Furthermore, wild\u2010type mice also developed dysphagia with ageing. Additionally, we studied pharyngeal muscles in a mouse model for oculopharyngeal muscular dystrophy, a dysphagic disease caused by a polyalanine expansion in the RNA binding protein, PABPN1. We examined pharyngeal muscles of mice overexpressing either wild\u2010type A10 or mutant A17 PABPN1. Overexpression of mutant A17 PABPN1 differentially affected growth of the palatopharyngeus muscle dependent on its location within the pharynx. Interestingly, overexpression of wild\u2010type A10 PABPN1 was protective against age\u2010related muscle atrophy in the laryngopharynx and prevented the development of age\u2010related dysphagia. These results demonstrate that pharyngeal muscles are differentially affected by both ageing and muscular dystrophy in a region\u2010dependent manner. These studies lay important groundwork for understanding the molecular and cellular mechanisms that regulate pharyngeal muscle growth and atrophy, which may lead to novel therapies for individuals with dysphagia.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jphysiol.2014.280420","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T05:52:55Z","timestamp":1413611575000},"page":"5301-5315","source":"Crossref","is-referenced-by-count":21,"title":["Ageing and muscular dystrophy differentially affect murine pharyngeal muscles in a region\u2010dependent manner"],"prefix":"10.1113","volume":"592","author":[{"given":"Matthew E.","family":"Randolph","sequence":"first","affiliation":[{"name":"Department of Pharmacology Emory University  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Physiology Emory University  Atlanta GA 30322 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