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In this review, we focus, not on RyR\/IP<jats:sub>3<\/jats:sub>R, but on other ion\u2010channels that are known to be present in the sarcoplasmic\/endoplasmic reticulum (ER\/SR) membranes. We review their putative physiological roles and the evidence suggesting that they may support the process of intracellular Ca<jats:sup>2+<\/jats:sup> release, either indirectly by manipulating ionic fluxes across the ER\/SR membrane or by directly interacting with a Ca<jats:sup>2+<\/jats:sup>\u2010release channel. These channels rarely receive scientific attention because of the general lack of information regarding their biochemical and\/or electrophysiological characteristics makes it difficult to predict their physiological roles and their impact on SR Ca<jats:sup>2+<\/jats:sup> fluxes. We discuss the possible role of SR K<jats:sup>+<\/jats:sup> channels and, in parallel, detail the known biochemical and biophysical properties of the trimeric intracellular cation (TRIC) proteins and their possible biological and pathophysiological roles in ER\/SR Ca<jats:sup>2+<\/jats:sup> release. We summarise what is known regarding Cl<jats:sup>\u2212<\/jats:sup> channels in the ER\/SR and the non\u2010selective cation channels or putative \u2018Ca<jats:sup>2+<\/jats:sup> leak channels\u2019, including mitsugumin23 (MG23), pannexins, presenilins and the transient receptor potential (TRP) channels that are distributed across ER\/SR membranes but which have not yet been fully characterised functionally.<\/jats:p>","DOI":"10.1113\/jphysiol.2014.281881","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T10:03:52Z","timestamp":1414145032000},"page":"3241-3251","source":"Crossref","is-referenced-by-count":69,"title":["New and notable ion\u2010channels in the sarcoplasmic\/endoplasmic reticulum: do they support the process of intracellular Ca<sup>2+<\/sup> release?"],"prefix":"10.1113","volume":"593","author":[{"given":"Hiroshi","family":"Takeshima","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Kyoto University  Kyoto 606\u20138501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Venturi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford OX1 3QT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sitsapesan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford OX1 3QT 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