{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:27:37Z","timestamp":1771622857207,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1967,1,1]],"date-time":"1967-01-01T00:00:00Z","timestamp":-94694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:p>1. A small volume of artificial sea water containing 300 n\n<jats:sc>M<\/jats:sc> tetrodotoxin (TTX) was applied successively to seven lobster nerve trunks and the cumulative uptake of toxin investigated by bio\u2010assay.<\/jats:p><jats:p>2. Light and electron microscopy indicated that the nerve trunks had a total axonal area of 0\u00b77 \u00d7 10<jats:sup>4<\/jats:sup> cm<jats:sup>2<\/jats:sup>\/g.<\/jats:p><jats:p>3. Sodium analysis gave a sodium space for the nerve trunks of 30%.<\/jats:p><jats:p>4. The amount of toxin taken up by the cells in 1 g of nerve is less than 1\u00b76 \u00d7 10<jats:sup>\u221211<\/jats:sup> moles.<\/jats:p><jats:p>5. It is argued that there are probably fewer than 13 sodium channels\/\u03bc<jats:sup>2<\/jats:sup> axon in lobster nerve.<\/jats:p>","DOI":"10.1113\/jphysiol.1967.sp008126","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T01:11:22Z","timestamp":1419037882000},"page":"99-105","source":"Crossref","is-referenced-by-count":109,"title":["An upper limit to the number of sodium channels in nerve membrane?"],"prefix":"10.1113","volume":"188","author":[{"given":"J. W.","family":"Moore","sequence":"first","affiliation":[]},{"given":"T.","family":"Narahashi","sequence":"additional","affiliation":[]},{"given":"T. I.","family":"Shaw","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1967,1]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1967.sp008126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1967.sp008126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:43:04Z","timestamp":1699454584000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1967.sp008126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1967,1]]}},"alternative-id":["10.1113\/jphysiol.1967.sp008126"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1967.sp008126","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,1]]}}}