{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:29:23Z","timestamp":1771622963726,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1967,4,1]],"date-time":"1967-04-01T00:00:00Z","timestamp":-86918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1967,4]]},"abstract":"<jats:p>1. The effect of changes in the pH of the extracellular solution on the membrane conductance of frog sartorius and toe muscle fibres was measured with intracellular micro\u2010electrodes.<\/jats:p><jats:p>2. In Ringer solution the membrane conductance was found to be highly sensitive to changes in pH between 5\u00b70 and 9\u00b78. In alkaline solution the conductance rose; in acid solution it fell.<\/jats:p><jats:p>3. After replacement of chloride by the relatively impermeant methylsulphate ion the membrane conductance showed little change when pH was altered. It is concluded that chloride is the ion species principally concerned in the pH sensitivity of the resting membrane conductance.<\/jats:p><jats:p>4. The relation between pH and the chloride conductance was sigmoid, with the steepest part of the curve lying in the region of neutrality.<\/jats:p><jats:p>5. The membrane conductance of muscles equilibrated in a 100 m\n<jats:sc>M<\/jats:sc>\u2010K 216 m\n<jats:sc>M<\/jats:sc>\u2010Cl solution was also sensitive to changes of extracellular pH. As in Ringer solution, the membrane conductance rose in alkaline and fell in acid solutions in a sigmoid fashion.<\/jats:p><jats:p>6. Sartorius muscles in isotonic potassium methylsulphate solution showed no change in membrane conductance at different pH values.<\/jats:p><jats:p>7. In chloride\u2010free solution a fall in pH tended to cause depolarization; a rise in pH had the opposite effect.<\/jats:p><jats:p>8. In Ringer solution the initial effect of a rise in pH was usually a transient depolarization. The indication is that the intracellular concentration of chloride ions may be slightly in excess of that which corresponds to the resting potential. The long\u2010term effects of changes in pH on the membrane potential in Ringer solution were in the same direction as in the absence of chloride.<\/jats:p><jats:p>9. The transient potential changes produced on addition and withdrawal of chloride ions were found to be larger in alkaline solutions than in acid solutions. This is further evidence for a higher chloride permeability in alkaline solutions.<\/jats:p>","DOI":"10.1113\/jphysiol.1967.sp008176","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T14:55:23Z","timestamp":1419000923000},"page":"403-425","source":"Crossref","is-referenced-by-count":104,"title":["The pH sensitivity of the chloride conductance of frog skeletal muscle"],"prefix":"10.1113","volume":"189","author":[{"given":"O. F.","family":"Hutter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1967,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1967.sp008176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1967.sp008176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:10:57Z","timestamp":1699452657000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1967.sp008176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1967,4]]}},"alternative-id":["10.1113\/jphysiol.1967.sp008176"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1967.sp008176","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,4]]}}}