{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:04:10Z","timestamp":1778274250314,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1968,7,1]],"date-time":"1968-07-01T00:00:00Z","timestamp":-47433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:p>1. Thin diaphragm muscles in dialysed serum maintained their total sodium at values similar to those found <jats:italic>in vivo<\/jats:italic>. The fibre sodium exchanged with a half\u2010time of 5 min, and the flux was 10 p\u2010mole.cm<jats:sup>\u22122<\/jats:sup>.sec<jats:sup>\u22121<\/jats:sup>. The internal sodium was less than 10 \u03bcmoles\/g fibre water and the ratio of external to internal sodium was at least 15. The calculated energy expenditure for sodium extrusion was less than 2% of the resting metabolism.<\/jats:p><jats:p>2. In physiological saline the half\u2010time for exchange of fibre sodium was similar to that in serum, but in saline there was an increase in sodium permeability and a raised total and fibre sodium.<\/jats:p><jats:p>3. Muscles treated with insulin (0\u00b702 u.\/ml.) showed a more rapid exchange of sodium compared with muscles in saline, with no change in the permeability to sodium. Insulin also affected sodium movements in the absence of external glucose.<\/jats:p><jats:p>4. In saline the fraction of sodium which exchanged rapidly occupied 0\u00b733 by volume of the muscle, after corrections for diffusion, and this value was similar to the mannitol space.<\/jats:p><jats:p>5. Fibre diameters were measured in frozen sections. Muscles prepared by fixation and embedding showed marked shrinkage.<\/jats:p>","DOI":"10.1113\/jphysiol.1968.sp008558","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T12:27:05Z","timestamp":1418992025000},"page":"255-278","source":"Crossref","is-referenced-by-count":64,"title":["Sodium fluxes in diaphragm muscle and the effects of insulin and serum proteins"],"prefix":"10.1113","volume":"197","author":[{"given":"R.","family":"Creese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Jenden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1968,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1968.sp008558","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1968.sp008558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T17:31:22Z","timestamp":1699464682000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1968.sp008558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,7]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,7]]}},"alternative-id":["10.1113\/jphysiol.1968.sp008558"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1968.sp008558","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,7]]}}}