{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:05:56Z","timestamp":1770343556898,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1969,8,1]],"date-time":"1969-08-01T00:00:00Z","timestamp":-13219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:p>1. Lung irritant receptors have been studied in rabbits by recording action potentials from single vagal nerve fibres. Some of the rabbits were bilaterally vagotomized, and some paralysed and artificially ventilated.<\/jats:p><jats:p>2. The receptors gave rapidly adapting irregular discharges on inflation and deflation of the lungs. Many were stimulated by insufflation of ammonia vapour into the lungs, and some by passage of a fine catheter into the right bronchial tree. The fibres had conduction velocities in the range 3\u00b76\u201325\u00b78 m\/sec.<\/jats:p><jats:p>3. The receptors were strongly stimulated by intravenous injections of histamine acid phosphate, 25\u2013100 \u03bcg\/kg. The response was considerably reduced by previous injection of isoprenaline which also reduced the bronchoconstriction due to histamine.<\/jats:p><jats:p>4. The receptors were stimulated by intravenous injections of isoprenaline, phenyl diguanide and micro\u2010emboli, and by anaphylaxis induced in rabbits previously sensitized to egg albumin.<\/jats:p><jats:p>5. The receptor responses could not be closely correlated in size with simultaneous changes in total lung resistance, lung compliance, tidal volume or breathing frequency.<\/jats:p><jats:p>6. It is concluded that, in rabbits with intact vagus nerves, lung irritant receptors contribute to the reflex hyperpnoea and bronchoconstriction of the conditions studied.<\/jats:p>","DOI":"10.1113\/jphysiol.1969.sp008867","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:57:48Z","timestamp":1418990268000},"page":"337-357","source":"Crossref","is-referenced-by-count":206,"title":["Activity of lung irritant receptors in pulmonary micro\u2010embolism, anaphylaxis and drug\u2010induced bronchoconstrictions"],"prefix":"10.1113","volume":"203","author":[{"given":"Janet E.","family":"Mills","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Sellick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Widdicombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1969,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1969.sp008867","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1969.sp008867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T20:01:57Z","timestamp":1699473717000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1969.sp008867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,8]]}},"alternative-id":["10.1113\/jphysiol.1969.sp008867"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1969.sp008867","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,8]]}}}