{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:31:12Z","timestamp":1775619072896,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1970,3,1]],"date-time":"1970-03-01T00:00:00Z","timestamp":5097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,3]]},"abstract":"<jats:p>1. Depression of transmitter release produced by preceding conditioning stimulation was studied at the frog's neuromuscular junction.<\/jats:p><jats:p>2. Depression occurred when transmitter release was restricted to a short length of nerve terminal, or when release was initiated by electrotonic depolarization of the terminals after action potentials were abolished by tetrodotoxin.<\/jats:p><jats:p>3. Quantitative studies revealed a non\u2010linear relationship between the estimated magnitude of \u2018zero\u2010time\u2019 depression and the amount of transmitter released by conditioning stimulation.<\/jats:p><jats:p>4. Two stimuli separated by 20\u2013200 msec were given and the ratio of the end\u2010plate potential amplitudes (<jats:italic>V<\/jats:italic><jats:sub>2<\/jats:sub>\/<jats:italic>V<\/jats:italic><jats:sub>1<\/jats:sub>) was measured. This amplitude ratio increased during depression produced by stimuli preceding the test pair.<\/jats:p><jats:p>5. These observations may be explained by assuming that depression is associated with a reduction in release probability as well as a depletion of transmitter available for release.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009034","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:21:21Z","timestamp":1418988081000},"page":"629-644","source":"Crossref","is-referenced-by-count":251,"title":["Depression of transmitter release at the neuromuscular junction of the frog"],"prefix":"10.1113","volume":"206","author":[{"given":"W. J.","family":"Betz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:41:08Z","timestamp":1699461668000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,3]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009034"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009034","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,3]]}}}