{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:26:10Z","timestamp":1777598770896,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1970,8,1]],"date-time":"1970-08-01T00:00:00Z","timestamp":18316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,8]]},"abstract":"<jats:p>1. The mechanism of procaine action on post\u2010synaptic receptors for acetylcholine was studied by recording the end\u2010plate current at membrane potentials ranging from about +30 to about \u2212140 mV.<\/jats:p><jats:p>2. It has been found that at resting membrane potential of about \u221260 to \u221280 mV the end\u2010plate current has a fast initial and a slow late component. During hyperpolarization of the muscle fibre the amplitude of the slow component is depressed and its half\u2010time lengthened. When the membrane potential is inverted the difference in the time course of both components is much less pronounced or absent.<\/jats:p><jats:p>3. It is suggested that procaine modifies the receptor response induced by acetylcholine, and that this modification is dependent on membrane potential.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009186","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:25:31Z","timestamp":1418988331000},"page":"689-699","source":"Crossref","is-referenced-by-count":58,"title":["The effect of procaine on neuromuscular transmission"],"prefix":"10.1113","volume":"209","author":[{"given":"M.","family":"Korda\u0161","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1970,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:35:00Z","timestamp":1699446900000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,8]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009186"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009186","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,8]]}}}