{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:30:01Z","timestamp":1757586601486},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1970,11,1]],"date-time":"1970-11-01T00:00:00Z","timestamp":26265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1970,11]]},"abstract":"<jats:p>1. In unanaesthetized rabbits the cerebral ventricles were perfused for 30\u201375 min from left lateral ventricle to cisterna magna with solutions of different composition, whilst rectal temperature was continuously recorded.<\/jats:p><jats:p>2. Temperature did not rise during the perfusion when the perfusing fluid consisted of artificial c.s.f.; it did rise, however, when the perfusing fluid consisted merely of a 0\u00b79% sodium chloride solution.<\/jats:p><jats:p>3. Temperature fell, though not in all rabbits, during the perfusion when the calcium in the perfusing fluid was increased from 1\u00b725 m\n<jats:sc>M<\/jats:sc>, the concentration in c.s.f. to 5 m\n<jats:sc>M<\/jats:sc>.<\/jats:p><jats:p>4. Magnesium chloride had only a weak action, in comparison to calcium, in preventing the rise produced during perfusion with 0\u00b79% sodium chloride solution. In a concentration of 1\u00b725 m\n<jats:sc>M<\/jats:sc> it had no effect, but in a concentration of 5 m\n<jats:sc>M<\/jats:sc> it delayed and greatly reduced the rise.<\/jats:p><jats:p>5. Temperature did not rise during perfusion with an isotonic sucrose solution.<\/jats:p><jats:p>6. The rise in temperature produced by an intravenous injection of leucocyte pyrogen was not prevented when the injection was made during a perfusion with artificial c.s.f., but it was prevented when the calcium concentration in the perfusing fluid was raised to 5 m\n<jats:sc>M<\/jats:sc> or when the perfusing fluid consisted of isotonic sucrose solution. Again, magnesium had only a weak action in comparison to calcium.<\/jats:p><jats:p>7. These results support the theory put forward recently (Feldberg, Myers &amp; Veale, 1970) that the constancy of temperature depends upon the physiological balance of sodium and calcium ions in the anterior hypothalamus, that the calcium ions act as a kind of \u2018brake\u2019 preventing the sodium ions from exerting their temperature raising effect, and that pyrogen acts by removing the \u2018calcium brake\u2019, the pyrogen fever thus being a sodium fever.<\/jats:p>","DOI":"10.1113\/jphysiol.1970.sp009277","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:29:45Z","timestamp":1418988585000},"page":"245-261","source":"Crossref","is-referenced-by-count":33,"title":["Mechanism of action of pyrogen"],"prefix":"10.1113","volume":"211","author":[{"given":"W.","family":"Feldberg","sequence":"first","affiliation":[]},{"given":"P. N.","family":"Saxena","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1970,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1970.sp009277","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1970.sp009277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T11:01:43Z","timestamp":1699441303000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1970.sp009277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,11]]}},"alternative-id":["10.1113\/jphysiol.1970.sp009277"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1970.sp009277","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,11]]}}}