{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:23:17Z","timestamp":1771629797372,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1971,4,1]],"date-time":"1971-04-01T00:00:00Z","timestamp":39312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1971,4]]},"abstract":"<jats:p>1. The intracellular Cl concentration of taenia coli cells, determined by an analytical procedure and by an extrapolation procedure, has a value between 60 and 73  m\u2010mole\/l. cell water.<\/jats:p><jats:p>2. This concentration is too high to be explained by a passive distribution. The discrepancy could be due to a binding of Cl in the intracellular or extracellular compartment or to an active uptake of Cl by the cells.<\/jats:p><jats:p>3. Determination of the activity coefficient for Cl in homogenates of smooth muscle did not support the hypothesis of binding of Cl ions.<\/jats:p><jats:p>4. The efflux of <jats:sup>36<\/jats:sup>Cl from taenia coli cells was not affected by foreign anions. After 1 hr exposure to a Cl\u2010free solution, the tissues contained less than 1  m\u2010mole of Cl\/kg wet wt., even if Cl had been replaced by a slowly penetrating anion. Because the intracellular cation concentration remained constant, it has to be assumed that new anionic groups can be formed in the cells.<\/jats:p><jats:p>5. The intracellular Cl concentration decreases during exposure to ouabain or to K\u2010free solution. The uptake seems therefore to be linked to the uptake of K through the Na pump.<\/jats:p><jats:p>6. Exposure to K\u2010free solution increases the K permeability of the membrane. Under the same experimental conditions the Cl permeability of the membrane increases as long as K is leaking out of the cells.<\/jats:p><jats:p>7. The anions in the external solution exert an important influence on the K permeability of the membrane. NO<jats:sub>3<\/jats:sub> and I cause a small increase of the permeability and large anions such as benzenesulphonate, propionate or pyroglutamate cause a pronounced decrease of this permeability.<\/jats:p>","DOI":"10.1113\/jphysiol.1971.sp009429","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:09:32Z","timestamp":1418987372000},"page":"225-243","source":"Crossref","is-referenced-by-count":45,"title":["The distribution of chloride ions in the smooth muscle cells of the guinea\u2010pig's taenia coli"],"prefix":"10.1113","volume":"214","author":[{"given":"R.","family":"Casteels","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1971,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1971.sp009429","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1971.sp009429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:19:11Z","timestamp":1699435151000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1971.sp009429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,4]]}},"alternative-id":["10.1113\/jphysiol.1971.sp009429"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1971.sp009429","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,4]]}}}