{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:28:58Z","timestamp":1771622938599,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>1. Force development and <jats:sup>45<\/jats:sup>Ca movement between the internal membranes and the myofilament space were measured in segments of skinned muscle fibres.<\/jats:p><jats:p>2. At 20\u00b0 C calcium ions in the myofilament space of calcium loaded fibres caused the internal membranes to release a substantial amount of calcium which produced a large force spike. Calcium produced a similar force spike in fibres containing only the physiological level of calcium when the temperature was lowered to about 6\u00b0 C.<\/jats:p><jats:p>3. The force spike at 6\u00b0 C was inhibited when the magnesium concentration in the bathing solution was increased from 1 to 6 m\n<jats:sc>M<\/jats:sc>. The pattern of force development in preparations transferred directly from oil to a free calcium solution indicated that the normal concentration of Mg<jats:sup>2+<\/jats:sup> in the myofilament space of intact fibres is of the order of 10<jats:sup>\u22123<\/jats:sup> \n<jats:sc>M<\/jats:sc>.<\/jats:p><jats:p>4. A possible role for the regenerative calcium release mechanism in the physiological activation of muscle fibres is suggested.<\/jats:p>","DOI":"10.1113\/jphysiol.1972.sp009831","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:39:01Z","timestamp":1418985541000},"page":"21-33","source":"Crossref","is-referenced-by-count":98,"title":["Intracellular calcium movements in skinned muscle fibres"],"prefix":"10.1113","volume":"223","author":[{"given":"L. E.","family":"Ford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Podolsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1972,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1972.sp009831","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1972.sp009831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T10:22:29Z","timestamp":1699438949000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1972.sp009831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1113\/jphysiol.1972.sp009831"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1972.sp009831","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5]]}}}