{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:01:38Z","timestamp":1780466498022,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1972,5,1]],"date-time":"1972-05-01T00:00:00Z","timestamp":73526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>1. End\u2010plate currents have been studied in glycerol\u2010treated frog sartorius nerve\u2014muscle preparations with the voltage clamp technique.<\/jats:p><jats:p>2. The effects of temperature on the decay rate of end\u2010plate currents were investigated over a temperature range from 10 to 30\u00b75\u00b0 C. The <jats:italic>Q<\/jats:italic><jats:sub>10<\/jats:sub> for the decay constant of end\u2010plate currents depends somewhat on membrane potential; at \u2014 100 mV the decay constant has a <jats:italic>Q<\/jats:italic><jats:sub>10<\/jats:sub> of 2\u00b77.<\/jats:p><jats:p>3. Peak end\u2010plate current depends non\u2010linearly on membrane potential with a decreasing slope conductance associated with hyperpolarization.<\/jats:p><jats:p>4. The \u2018instantaneous\u2019 voltage\u2014current relationship for end\u2010plate channels was determined by causing step changes in membrane potential during end\u2010plate current flow. This relationship appears to be linear.<\/jats:p><jats:p>5. The interaction of acetylcholine with its receptor is viewed as being analogous to the first step in enzymic catalysis. On this view, acetylcholine binds to its receptor and induces a conformational change which is responsible for opening end\u2010plate channels. By analogy to the first steps in the catalytic sequence of enzymes, the binding step is very rapid, almost diffusion\u2010limited, and the conformational change is rate\u2010limiting.<\/jats:p><jats:p>6. Equations describing this process have been derived. Expressions for the rate constants have also been derived by considering changing dipole moments of the transmitter\u2010receptor complex associated with the conformational change. As the transmitter\u2010receptor complex is in the membrane field, different conformational states have different energies, and the rate of conformational change thus depends on membrane potential. The equations thus derived are shown to account adequately for the time course of end\u2010plate conductance change.<\/jats:p>","DOI":"10.1113\/jphysiol.1972.sp009840","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:39:01Z","timestamp":1418985541000},"page":"173-197","source":"Crossref","is-referenced-by-count":383,"title":["A quantitative description of end\u2010plate currents"],"prefix":"10.1113","volume":"223","author":[{"given":"K. L.","family":"Magleby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1972,5]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1972.sp009840","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1972.sp009840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T10:22:21Z","timestamp":1699438941000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1972.sp009840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1113\/jphysiol.1972.sp009840"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1972.sp009840","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5]]}}}