{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:28:22Z","timestamp":1771622902944,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1972,6,1]],"date-time":"1972-06-01T00:00:00Z","timestamp":76204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1972,6]]},"abstract":"<jats:p>1. Intracellular records from <jats:italic>Aplysia<\/jats:italic> giant (R2) cell somata showed long lasting 4\u201310 mV hyperpolarizations after passage of outward current through a second intracellular electrode.<\/jats:p><jats:p>2. An increase in membrane slope conductance occurred simultaneously with the post\u2010stimulus hyperpolarization (PSH).<\/jats:p><jats:p>3. Both the PSH and conductance\u2010increase varied strongly with stimulus amplitude and duration.<\/jats:p><jats:p>4. Both the PSH and the conductance increase occurred in Ca\u2010free medium containing tetrodotoxin, when action\u2010potential production was completely blocked.<\/jats:p><jats:p>5. The PSH persisted in the presence of ouabain or DNP, with cooling, with removal of external K<jats:sup>+<\/jats:sup>, and in media where all the Na<jats:sup>+<\/jats:sup> was replaced with Li<jats:sup>+<\/jats:sup>, suggesting that it was not due to the activity of an electrogenic pump.<\/jats:p><jats:p>6. A reversal potential for the PSH was demonstrated by application of maintained inward current following the end of an outward\u2010directed stimulus.<\/jats:p><jats:p>7. The PSH reversal potential varied with [K]<jats:sub>o<\/jats:sub>, but not with [Cl]<jats:sub>o<\/jats:sub> or [Na]<jats:sub>o<\/jats:sub>, suggesting that the PSH was mainly due to an increase in K conductance.<\/jats:p><jats:p>8. The PSH and the conductance increase were reduced strongly when all the Na<jats:sup>+<\/jats:sup> was replaced with Tris, and only slightly when Na<jats:sup>+<\/jats:sup> was replaced with sucrose.<\/jats:p>","DOI":"10.1113\/jphysiol.1972.sp009862","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:38:05Z","timestamp":1418985485000},"page":"549-570","source":"Crossref","is-referenced-by-count":55,"title":["Post\u2010stimulus hyperpolarization and slow potassium conductance increase in <i>Aplysia<\/i> giant neurone"],"prefix":"10.1113","volume":"223","author":[{"given":"M. S.","family":"Brodwick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Junge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1972,6]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1972.sp009862","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1972.sp009862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T10:35:15Z","timestamp":1699439715000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1972.sp009862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,6]]}},"alternative-id":["10.1113\/jphysiol.1972.sp009862"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1972.sp009862","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,6]]}}}