{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:30:26Z","timestamp":1771623026716,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1974,4,1]],"date-time":"1974-04-01T00:00:00Z","timestamp":134006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1974,4]]},"abstract":"<jats:p>1. Changes of extracellular K<jats:sup>+<\/jats:sup> concentration, [K]<jats:sub>e<\/jats:sub>, arising in the spinal cord of the cat in response to an afferent stimulation were studied by means of K<jats:sup>+<\/jats:sup>\u2010specific micro\u2010electrodes.<\/jats:p><jats:p>2. In the most active areas of the spinal cord a single volley in a large afferent input like the common peroneal nerve or the posterior tibial nerve produced a transient increase in [K]<jats:sub>e<\/jats:sub> of 0\u00b705\u20130\u00b71 m\n<jats:sc>M<\/jats:sc>, which reached its peak in 0\u00b72\u20130\u00b73 sec and it declined in about 3 sec.<\/jats:p><jats:p>3. Much higher increases in [K]<jats:sub>e<\/jats:sub> were found during repetitive stimulation of an afferent input. The highest increase (by 3 m\n<jats:sc>M<\/jats:sc>) was at 100 Hz, but even at 1 Hz a significant increase of 0\u00b725 m\n<jats:sc>M<\/jats:sc> was observed. Equilibration of accumulated K<jats:sup>+<\/jats:sup> was slow with a time constant of about 6 sec, which is much longer than could be expected for the same process in free solution.<\/jats:p><jats:p>4. A characteristic distribution of increased [K]<jats:sub>e<\/jats:sub> was found in the spinal cord in response to 100 Hz afferent stimulation. The highest increase of 3 m\n<jats:sc>M<\/jats:sc> was found in and around the intermediate nucleus, but at depths between 0\u00b79\u20131\u00b78 mm the [K]<jats:sub>e<\/jats:sub> increase exceeded 1 m\n<jats:sc>M<\/jats:sc>.<\/jats:p><jats:p>5. In the ventral horns afferent stimulation (100 Hz) increased [K]<jats:sub>e<\/jats:sub> by 0\u00b725 m\n<jats:sc>M<\/jats:sc>, while the same stimulation of the ventral root resulted in a [K]<jats:sub>e<\/jats:sub> increase of less than 0\u00b705 m\n<jats:sc>M<\/jats:sc>.<\/jats:p><jats:p>6. The consequences of K<jats:sub>e<\/jats:sub><jats:sup>+<\/jats:sup> accumulation after neuronal discharge are discussed in respect to its possible role in the depolarization of primary afferent terminals.<\/jats:p>","DOI":"10.1113\/jphysiol.1974.sp010507","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:19:49Z","timestamp":1418984389000},"page":"1-15","source":"Crossref","is-referenced-by-count":118,"title":["Changes of of extracellular potassium concentration induced by neuronal activity in the spinal cord of the cat"],"prefix":"10.1113","volume":"238","author":[{"given":"N.","family":"K\u0159\u00ed\u017e","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Sykov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ujec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vyklick\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,4]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1974.sp010507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1974.sp010507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T06:48:21Z","timestamp":1699166901000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1974.sp010507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,4]]}},"alternative-id":["10.1113\/jphysiol.1974.sp010507"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1974.sp010507","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,4]]}}}