{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:30:13Z","timestamp":1771623013237,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1975,3,1]],"date-time":"1975-03-01T00:00:00Z","timestamp":162864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1975,3]]},"abstract":"<jats:p>1. In the isolated frog spinal cord picrotoxin, bicuculline, and strychnine were evaluated for their effects on synaptically induced root potentials recorded by the sucrose gap technique. 2. Picrotoxin (greater than 10\u2010 minus 4 M) completely blocked the dorsal root potential (DRP) elicited by stimulating the ventral root of the same segment (VR\u2010DRP). Although picrotoxin antagonized the DRP elicited by stimulation of either an adjacent dorsal root (DR\u2010DRP) or the lateral column (LC\u2010DRP), a slower component to these  potentials appeared and increased in size as the concentration of picrotoxin was increased. Thus picrotoxin brings out a later, picrotoxin resistant component to the DR\u2010DRP and LC\u2010DRP. 3. Strychnine (10\u2010 minus 8\u201310\u2010 minus 5 M) reduced and abolished the VR\u2010DRP without prolongation and progressively increased and prolonged the DR\u2010DRP (and LC\u2010DRP) and the DR\u2010VRP. Strychnine in higher concentrations (greater than 10\u2010 minus 4 M) also reduced the amplitude and prolonged the duration of the compound action potential of afferent fibres. 4. These results combined with those presented in the preceding paper (Barker, Nicoll &amp; Padjen, 1975) suggest that (1) a GABA\u2010like transmitter mediates the final step in the DR\u2010DRP and LC\u2010DRP pathways and that (2) either taurine or beta\u2010alanine may mediate the last step in the VR\u2010DRP pathway.<\/jats:p>","DOI":"10.1113\/jphysiol.1975.sp010860","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:18:50Z","timestamp":1418980730000},"page":"537-548","source":"Crossref","is-referenced-by-count":85,"title":["Studies on convulsants in the isolated frog spinal cord. II. Effects on root potentials."],"prefix":"10.1113","volume":"245","author":[{"given":"J L","family":"Barker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Padjen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1975,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1975.sp010860","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1975.sp010860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T16:52:45Z","timestamp":1699203165000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1975.sp010860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,3]]}},"alternative-id":["10.1113\/jphysiol.1975.sp010860"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1975.sp010860","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,3]]}}}