{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:00:21Z","timestamp":1759683621762},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1975,7]]},"abstract":"<jats:p>1. The effect of procaine on acetylcholine\u2010induced membrane fluctuations (ACh noise) was studied by intracellular and focal external recording from end\u2010plates of frog sartorius muscle. 2. With intracellular recording, ACh noise (the ratio of variance to mean depolarization) was substantially reduced by procaine, suggesting a greatly decreased amplitude of the elementary potential change. 3. Spectral analysis of the ACh noise indicated a dual average time course of the underlying \u201cshot effects\", similar to the complex shape (brief spike followed by a long tail of low intensity) of the end\u2010plate current in pro\u2010aine\u2010treated muscle. 4. The post\u2010synaptic blocking action of procaine can be largely explained by the drastic shortening of the initial high\u2010intensity phase of the end\u2010plate conductance change. 5. The average time course of the ACh shot effects is discussed in terms of alternative hypotheses, one attributing the complex shape to each elementary event, the other involving sequential reaction steps which produce two unequal populations of ion gates of different \u201clife\u2010times\u201d.<\/jats:p>","DOI":"10.1113\/jphysiol.1975.sp011015","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:27:06Z","timestamp":1418981226000},"page":"269-284","source":"Crossref","is-referenced-by-count":59,"title":["The effect of procaine on the action of acetylcholine at the neuromuscular junction."],"prefix":"10.1113","volume":"249","author":[{"given":"B","family":"Katz","sequence":"first","affiliation":[]},{"given":"R","family":"Miledi","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1975,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1975.sp011015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1975.sp011015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T04:12:43Z","timestamp":1699243963000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1975.sp011015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,7]]}},"alternative-id":["10.1113\/jphysiol.1975.sp011015"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1975.sp011015","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,7]]}}}