{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:53:07Z","timestamp":1772941987188,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1975,11,1]],"date-time":"1975-11-01T00:00:00Z","timestamp":184032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1975,11]]},"abstract":"<jats:p>1. HCO\u20103, Na+ and K+ concentrations were measured in bile\u2010free pancreatic juice collected from fasted and fed anaesthetized rats. 2. Resting flow rates averaged 0.62 mul. g\u20101 .min\u20101 (fasted) and 2.8 mul. g\u20101. min\u20101 (fed) and the mean HCO\u20103 concentrations, respectively, were 25.8 and 33.3 mM. 3. In fasted rats, instillation of HCl into the duodenum caused flow rate to increase threefold and HCO\u20103 concentrations to double (66 mM). Intravenous infusion of pure natural (GIH) secretin caused a fivefold increase in flow rate; HCO\u20103 concentrations, again, doubled (67.5 mM). Infusion of synthetic secretin produced effects essentially the same as those produced by GIH secretin. 4. Infusion of Boots secretin caused a thirteenfold increase in flow rate (8.32 mul.g\u20101. min\u20101) but HCO\u20103 concentrations rose only slightly (43.3 mM). However, following cessation of infusion, when flow rate approximated the maximum obtained with pure secretin, the HCO\u20103 concentration was much higher (57.2 mM at 3.19 uml.g\u20101.min\u20101). In fed animals the responses were similar but maximum flow rates were greater (12 mul. g\u20101. min\u20101). 5. Infusion of caerulein produced a secretory rate slightly less than with Boots secretin (5.06 mul. g\u20101.min\u20101) and HCO\u20103 concentrations were plasmalike (30.2 mM); infusion of the synthetic octapeptide of cholecystokinin (OP\u2010CCK) gave similar flow rates and HCO\u20103 concentrations. 6. Infusion of a mixture of caerulein and GIH secretin mimicked closely the effect of Boots secretin. At maximum flow rates (7.6 mul. g\u20101. min\u20101) the HCO\u20103 concentration was 43.7 mM and at lower flow rates (3.90 mul.g\u20101. min\u20101) it rose to 54.2mM. 7. It is concluded that the response of the rat pancreas to secretin is qualitatively similar to that of all other vertebrates so far studied, but, relative to other animals, the response is sluggish. In contrast, the rat pancreas responds well to cholecystokinin (CCK) stimulation, yielding a juice with plasma\u2010like HCO\u20103 concentration. Boots secretin, which is heavily contaminated with CCK, causes a mixed response resembling that of CCK at high secretory rates and that of pure secretin at lower rates. 8. An unexplained feature of rat pancreatic juice was that K+ concentrations, although plasma\u2010like in unstimulated samples, rose to about 8mM when flow rate increases as a result of secretin, but not CCK, stimulation. In all other animals so far studied, the K+ concentration has been found to be independent of flow rate.<\/jats:p>","DOI":"10.1113\/jphysiol.1975.sp011149","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T09:29:42Z","timestamp":1418981382000},"page":"379-396","source":"Crossref","is-referenced-by-count":92,"title":["Secretion of electrolytes by the pancreas of the anaestetized rat."],"prefix":"10.1113","volume":"252","author":[{"given":"W A","family":"Sewell","sequence":"first","affiliation":[]},{"given":"J A","family":"Young","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1975,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1975.sp011149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1975.sp011149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:41:41Z","timestamp":1699270901000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1975.sp011149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,11]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,11]]}},"alternative-id":["10.1113\/jphysiol.1975.sp011149"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1975.sp011149","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,11]]}}}