{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T07:12:34Z","timestamp":1699773154598},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>1. A late inward current following the initial sodium current is sometimes observed on frog single skeletal muscle fibres studied in voltage\u2010clamp conditions by the double sucrose\u2010gap method. 2. The late inward current is time and voltage dependent; it is sensitive to extracellular sodium concentration and inhibited by tetrodotoxin. Therefore, it is very probably carried by sodium ions. 3. It is assumed that the late current reflects a regenerative increase of sodium conductance in the tubular membrane. The main argument favouring this assumption is that the late current is never observed on detubulated fibres. 4. Inactivation studies show a marked difference between the evolution of the two inward currents when the membrane resting potential is increased by previous hyperpolarizations in a high range of values: the late current is decreased while the initial current remains constant. The decrease of the late current is suppressed by tetraethylammonium ions or in a potassium\u2010free medium. On detubulated fibres, the sodium current is never decreased by conditioning hyperpolarizations. 5. It is postulated that a fast transient potassium current, located in the bubular membrane, should develop contemporaneously with the sodium current. 6. The decay of the sodium inactivation is anaylsed on semilogarithmic plot: on normal fibres, it runs in two phases while on detubulated fibres, one phase only is found.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp011918","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:38:43Z","timestamp":1418978323000},"page":"605-625","source":"Crossref","is-referenced-by-count":12,"title":["Voltage\u2010clamp experiments on frog single skeletal muscle fibres: evidence for a tubular sodium current."],"prefix":"10.1113","volume":"269","author":[{"given":"M","family":"Mandrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,8]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp011918","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp011918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T17:23:47Z","timestamp":1699205027000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp011918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["10.1113\/jphysiol.1977.sp011918"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp011918","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}