{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:33:07Z","timestamp":1762075987639},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1977,11,1]],"date-time":"1977-11-01T00:00:00Z","timestamp":247190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p>1. The ability of preganglionic axons to re\u2010establish their normal pattern of synaptic connexions with superior cervical ganglion cells has been studied after section of the cervical sympathetic trunk.<\/jats:p><jats:p>2. <jats:italic>In vivo<\/jats:italic> stimulation of the last cervical (C8) and the first seven thoracic ventral roots (T1\u2014T7) 3\u20104 months after section of the trunk produced end\u2010organ responses similar to those observed in normal animals.<\/jats:p><jats:p>3. The pattern of innervation of individual neurones, determined by intracellular recording of synaptic potentials 4\u20109 months after cutting the sympathetic trunk, was also similar to that observed in normal neurones. Both normal and re\u2010innervated ganglion cells were contacted by pre\u2010ganglionic axons arising from C8 to T7, and each neurone was usually innervated by a contiguous subset of these segments.<\/jats:p><jats:p>4. Re\u2010innervated neurones, as normal cells, were typically dominated by the innervation from a particular spinal cord segment, with the adjacent segments contributing a synaptic influence that decreased as a function of distance from the dominant segment. This was true whether the amplitude of the post\u2010synaptic potential, or the estimated number of contributing axons, was used as the criterion of segmental dominance.<\/jats:p><jats:p>5. Re\u2010innervated neurones, however, showed some abnormalities. The average number of ventral roots contributing innervation to each neurone was reduced from 4\u00b71 to 3\u00b70, and discontinuities in the sequence of innervating segments were more frequent than in normal neurones. Moreover, fewer preganglionic axons contacted each neurone after regeneration.<\/jats:p><jats:p>6. A further difference between normal and re\u2010innervated neurones during the period covered by these experiments was that axons from the more caudal spinal cord segments were less successful in re\u2010establishing contacts with ganglion cells than those from the rostral segments. The more caudal the position of the preganglionic neurones, the more pronounced was this relative deficiency.<\/jats:p><jats:p>7. Although anomalies of ganglion cell innervation were apparent, the basis for the restoration of normal functional effects appears to be the re\u2010establishment of a pattern of innervation of individual neurones similar to that observed in normal ganglia.<\/jats:p>","DOI":"10.1113\/jphysiol.1977.sp012064","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:15:06Z","timestamp":1418976906000},"page":"633-651","source":"Crossref","is-referenced-by-count":38,"title":["Re\u2010innervation of guinea\u2010pig superior cervical ganglion cells by preganglionic fibres arising from different levels of the spinal cord"],"prefix":"10.1113","volume":"272","author":[{"given":"Arild","family":"Nj\u00e5","sequence":"first","affiliation":[]},{"given":"Dale","family":"Purves","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1977,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1977.sp012064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1977.sp012064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:16:00Z","timestamp":1699269360000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1977.sp012064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,11]]}},"alternative-id":["10.1113\/jphysiol.1977.sp012064"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1977.sp012064","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}