{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:58:51Z","timestamp":1758279531964},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,7,1]],"date-time":"1979-07-01T00:00:00Z","timestamp":299635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,7]]},"abstract":"<jats:p>1. The Ca2+ inward current (ICa) and a slow outward current in differentiated cells of mouse neuroblastoma clone N1E\u2010115 have been studied under voltage\u2010clamp conditions. 2. ICa shows voltage\u2010 and time\u2010dependent inactivation when evoked by step\u2010wise depolarizations in Na+\u2010free solution containing high [Ca2+] (20 nM) and tetraethylammonium (TEA, 25 mM). Ba2+ and Sr2+ can substitute for Ca2+. 3. Holding potentials below \u201070 mV maximal activate ICa. Half inactivation occurs at \u201056 mV and ICa is completely inactivated beyond holding levels of \u201030 mV. Maximum peak currents are of the order of 10(\u20104) A\/cm2 and the reversal potential ranges from +40 to +60 mV. The ICa inactivation time course follows first\u2010order kinetics with a voltage\u2010depedent time constant ranging from 25 to 100 msec. 4. The striking resemblance between ICa and the Ca2+ current in the unfertilized mouse oocyte (Okamoto, Takahashi &amp; Yamashita, 1977) is discussed. 5. A slow outward current with a rise time of several seconds is recorded on voltage steps beyond \u201020 mV in high [Ca2+] solutions. It is carried primarily by K+ on account of the value of the reversal potential and its dependence on [K]0. This K+ current is TEA\u2010insensitive and is blocked by Ca2+ antagonists. 6. The slow K+ current (IK(Ca)) is suggested to be mediated by Ca2+ influx, but the voltage\u2010dependence of the underlying conductance (GK(Ca)) differs significantly from the ICa voltage\u2010dependence. 7. The results are consistent with the hypothesis that IK(Ca) depends both on ICa and on membrane potential. An alternative hypothesis is briefly discussed.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp012852","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T02:31:05Z","timestamp":1418956265000},"page":"307-323","source":"Crossref","is-referenced-by-count":60,"title":["The calcium current and the activation of a slow potassium conductance in voltage\u2010clamped mouse neuroblastoma cells."],"prefix":"10.1113","volume":"292","author":[{"given":"W H","family":"Moolenaar","sequence":"first","affiliation":[]},{"given":"I","family":"Spector","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1979,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp012852","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp012852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T01:08:05Z","timestamp":1699146485000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp012852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,7]]}},"alternative-id":["10.1113\/jphysiol.1979.sp012852"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp012852","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,7]]}}}