{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:55Z","timestamp":1761519115729},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,12,1]],"date-time":"1979-12-01T00:00:00Z","timestamp":312854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:p>1. The steady\u2010state heat production rate (E) of soleus muscles obtained from adult mice in various thyroid states was measured in a perfused microcalorimeter. The ouabain\u2010suppressible fractions of E and 42K influx were compared and the energetic efficiency of active Na\u2010K transport assessed. 2. Hypothyroidism with plasma thyroxine concentrations below 1 microgram\/100 ml. was induced by pretreatment with 131I or perchlorate. In soleus muscles isolated from treated animals, mean E values were 25.1 +\/\u2010 0.7 and 24.2 +\/\u2010 0.5 mcal.g wet wt.\u20101.min\u20101 for the 131I and the perchlorate series respectively, i.e. about 30% lower than the control level (36.3 +\/\u2010 1.5 mcal.g wet wt.\u20101.min\u20101). Following triiodothyronine treatment, E was increased by about 45%. 3. In muscles from hypothyroid (131I and perchlorate series), euthyroid and hyperthyroid mice ouabain (10(\u20103) M) induced a rapid decrease in E of 1.6 +\/\u2010 0.1 and 1.4 +\/\u2010 0.1, 2.5 +\/\u2010 0.2, and 4.3 +\/\u2010 0.6 mcal.g wet wt.\u20101.min\u20101 respectively, i.e. between 6 and 8% of E. 4. In muscles obtained from hypothyroid, euthyroid and hyperthyroid mice, the ouabain\u2010suppressible component of 42K influx was 0.17 +\/\u2010 0.04, 0.31 +\/\u2010 0.02 and 0.45 +\/\u2010 0.02 micromole. g wet wt.\u20101.min\u20101 respectively. Whereas the total number of ouabain binding sites varied appreciably with the thyroid status, the Na\u2010K contents of soleus or diaphragm muscles showed no significant changes. 5. Notwithstanding the parallelism between the changes in basal E and ouabain\u2010sensitive components of E and K influx with the thyroid status, it is concluded that active NA\u2010K transport cannot be considered a primary effector of thyroid thermogenesis in intact mammalian skeletal muscle. The direct contribution of active NA\u2010K transport to this thermogenesis was indeed small compared with the over\u2010all cellular energy dissipation. 6. The minimum over\u2010all energetic efficiency of the transport process in the intact muscles (30\u2010\u201035%) was not dependent on the thyroid status.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp013026","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:28:31Z","timestamp":1418974111000},"page":"47-60","source":"Crossref","is-referenced-by-count":78,"title":["Thyroid hormones and the energetics of active sodium\u2010potassium transport in mammalian skeletal muscles."],"prefix":"10.1113","volume":"297","author":[{"given":"R","family":"Biron","sequence":"first","affiliation":[]},{"given":"A","family":"Burger","sequence":"additional","affiliation":[]},{"given":"A","family":"Chinet","sequence":"additional","affiliation":[]},{"given":"T","family":"Clausen","sequence":"additional","affiliation":[]},{"given":"R","family":"Dubois\u2010Ferri\u00e8re","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1979,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp013026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp013026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T21:57:49Z","timestamp":1699221469000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp013026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,12]]}},"alternative-id":["10.1113\/jphysiol.1979.sp013026"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp013026","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}