{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:55:00Z","timestamp":1757541300211},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,12,1]],"date-time":"1979-12-01T00:00:00Z","timestamp":312854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:p>1. In sheep Purkinje fibre preparations, salicylate ions produce reversible changes in resting potential and in action potential duration. In most preparations these effects resemble those produced by \u2010ow extracellular K concentration: the resting potential first increases and then decreases, the action potential is prolonged and eventually, low potential oscillations occur in the plateau range. In a few preparations, action potential shortening occurs. 2. The threshold current for initiating action potentials by an intracellular electrode is reversibly increased by salicylate. 3. The activation curve, soo(Em), for the pace\u2010maker K current, iK2, shifted in a hyperpolarizing direction. The magnitude of the shift is about \u20105 mV in 5 mM\u2010salicylate and \u201030 mV in 50 mM\u2010salicylate. 4. The apparent reversal potential for iK2 is shifted in a negative direction. The magnitude of this shift at a given salicylate concent;ation varies with the K concentration. In an extracellular K concentration of 2.7 mM an average shift of \u201018 mV occurs in 10 mM\u2010salicylate; in 8 mM, the average shift is only \u20101 mV. 5. It is proposed that most of these effects may be produced by an increase in surface negative potential produced by the binding of salicylate to the cell membrane. This would produce the hyperpolarizing shift of activation curves for ionic current and, by increasing surface K activity, may lead to stimulation of the Na\u2010K pump to produce an increase in the K gradient across the cell membrane.<\/jats:p>","DOI":"10.1113\/jphysiol.1979.sp013033","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:28:31Z","timestamp":1418974111000},"page":"163-185","source":"Crossref","is-referenced-by-count":29,"title":["Action of salicylate ions on the electrical properties of sheep cardiac Purkinje fibres."],"prefix":"10.1113","volume":"297","author":[{"given":"I","family":"Cohen","sequence":"first","affiliation":[]},{"given":"D","family":"Noble","sequence":"additional","affiliation":[]},{"given":"M","family":"Ohba","sequence":"additional","affiliation":[]},{"given":"C","family":"Ojeda","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1979,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1979.sp013033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1979.sp013033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T21:58:04Z","timestamp":1699221484000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1979.sp013033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,12]]}},"alternative-id":["10.1113\/jphysiol.1979.sp013033"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1979.sp013033","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}