{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:25:26Z","timestamp":1781108726841,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:p>1. Small preparations of spontaneously beating rabbit sino\u2010atrial node have been investigated using the two micro\u2010electrode voltage\u2010clamp technique. 2. Hyperpolarizing clamp pulses given from holding potentials of about \u201045 mV reveal a time\u2010dependent change of a membrane current, if, which is shown to overlap the pace\u2010maker range (\u201065 mV to \u201045 mV) for these preparations. 3. The changes in if are shown to be quite distinct from the de\u2010activation of the time\u2010dependent outward current, iK. 4. The time\u2010dependent changes of the if system increase during adrenaline application and therefore contribute to the chronotropic action of adrenaline on the heart. 5. Evidence for a link between slow inward current (iSi) and time\u2010dependent outward current (iK) in rabbit sino\u2010atrial node is presented and assessed.<\/jats:p>","DOI":"10.1113\/jphysiol.1980.sp013474","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:18:42Z","timestamp":1418973522000},"page":"331-351","source":"Crossref","is-referenced-by-count":227,"title":["Voltage\u2010clamp investigations of membrane currents underlying pace\u2010maker activity in rabbit sino\u2010atrial node."],"prefix":"10.1113","volume":"308","author":[{"given":"H","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Difrancesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1980,11]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1980.sp013474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1980.sp013474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:45:19Z","timestamp":1699231519000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1980.sp013474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1113\/jphysiol.1980.sp013474"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1980.sp013474","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}