{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T01:43:38Z","timestamp":1713404618833},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1981,12,1]],"date-time":"1981-12-01T00:00:00Z","timestamp":376012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:p>1. A two\u2010electrode voltage clamp method was used to study Ca inward currents in identified Helix aspersa neurones bathed in 25 mM\u2010Ca, Na\u2010free saline with TEA and 4\u2010AP. 2. Inward currents were blocked by CdCl2. In Cd delayed outward currents appeared at +30 mV. When two identical depolarizations were separated by a gap inward current turned off to the same level during the two pulses up to +20 mV; above this potential the records cross over. 3. The turn\u2010off of inward current at potentials up to +20 mV was not affected by 0.2 mM\u2010quinine, which reduced outward currents at more depolarized potentials. Inward currents declined exponentially over the first 100 msec with a time constant around 60 msec at 0 mV. Double\u2010pulse experiments gave the same time course of turn\u2010off. 4. When Ca inward current was reduced by lowering [Ca]o or by partial block by Cd the rate and extent of turn\u2010off was reduced. 5. The inactivation curve (obtained using a double pulse with gap method) was U\u2010shaped. The curve was not significantly changed by addition of quinine (0.2 mM) or by changing test pulse size. 6. Recovery of inward currents after a depolarizing prepulse was a double\u2010exponential process, with time constants of 120 msec and 9.4 sec at 10\u2010\u201011 degrees C. 7. Our results are discussed in terms of possible Ca\u2010dependent Ca inactivation and in terms of the possibility of development of an outward Ca\u2010dependent K current.<\/jats:p>","DOI":"10.1113\/jphysiol.1981.sp013983","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T07:09:00Z","timestamp":1418972940000},"page":"273-285","source":"Crossref","is-referenced-by-count":43,"title":["Calcium current inactivation in identified neurones of Helix aspersa."],"prefix":"10.1113","volume":"321","author":[{"given":"T D","family":"Plant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N B","family":"Standen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1981.sp013983","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1981.sp013983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:01:39Z","timestamp":1699246899000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1981.sp013983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["10.1113\/jphysiol.1981.sp013983"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1981.sp013983","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]}}}