{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:32:51Z","timestamp":1780587171611,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:p>The membrane of tissue\u2010cultured chick pectoral muscle contains an ionic channel which is activated by membrane stretch. Nicotinic channels and Ca2+\u2010activated K+ channels are not affected by stretch. In 150 mM\u2010external K+ and 150 mM\u2010internal Na+ the channel has a conductance of 70 pS, linear current\u2010voltage relationship between \u201050 and \u2010140 mV and a reversal potential of +30 mV. Kinetic analysis of single\u2010channel records indicates that there are one open (O) and three closed (C) states. The data can be fitted by the reaction scheme: C1\u2010C2\u2010C3\u2010O. Only the rate constant that governs the C1\u2010C2 transition (k1,2) is stretch\u2010sensitive. None of the rates are voltage\u2010sensitive. The rate constant k1,2 varies with the square of the tension as k1, 2 = k0 X e alpha T2, where alpha is a constant describing the sensitivity to stretch and T is the tension. A typical value of alpha is 0.08 (dyn cm\u20101)\u20102. Following exposure to cytochalasin B the channel becomes more sensitive to stretch. The stretch\u2010sensitivity constant, alpha, increases from 0.08 to 2.4 (dyn cm\u20101)\u20102. The probability of the channel being open is strongly dependent upon the extracellular K+ concentration. With a suction of 2 cmHg the probability increases from 0.004 in normal saline (5 mM\u2010K+) to 0.26 in 150 mM\u2010K+. The channel appears to gather force from a large area of membrane (greater than 3 X 10(5) A2), probably by a cytochalasin\u2010resistant cytoskeletal network.<\/jats:p>","DOI":"10.1113\/jphysiol.1984.sp015317","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:49:28Z","timestamp":1418971768000},"page":"685-701","source":"Crossref","is-referenced-by-count":757,"title":["Stretch\u2010activated single ion channel currents in tissue\u2010cultured embryonic chick skeletal muscle."],"prefix":"10.1113","volume":"352","author":[{"given":"F","family":"Guharay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1984,7]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1984.sp015317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1984.sp015317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:06:14Z","timestamp":1697771174000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1984.sp015317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,7]]}},"alternative-id":["10.1113\/jphysiol.1984.sp015317"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1984.sp015317","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}