{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:42:35Z","timestamp":1773679355184,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,12,1]],"date-time":"1991-12-01T00:00:00Z","timestamp":691545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>1. The effects of metabotropic glutamate receptor agonists on excitatory synaptic transmission in the CA1 region of rat hippocampal slices (11\u201030 days) were studied using extracellular and whole\u2010cell patch\u2010clamp recording techniques. 2. Trans\u20101\u2010amino\u20101,3\u2010cyclopentanedicarboxylic acid (trans\u2010ACPD; 25\u2010100 microM) reversibly depressed excitatory postsynaptic currents (EPSCs) without affecting presynaptic fibre excitability or EPSC reversal potential. 3. Ibotenate (25 microM) or L\u2010glutamate (250 microM), in the presence of the N\u2010methyl\u2010D\u2010aspartate (NMDA) receptor antagonist, D\u20102\u2010amino\u20105\u2010phosphonovaleric acid (APV, 50\u201075 microM), depressed the EPSC amplitude while inducing no detectable inward current. L\u20102\u2010Amino\u20104\u2010phosphonobutyrate (L\u2010AP4, 25\u2010100 microM), the phosphonic derivative of glutamate, also depressed EPSC amplitude and caused no detectable inward current. 4. The NMDA receptor\u2010mediated component of the EPSC recorded in the presence of the non\u2010NMDA receptor antagonist, 6\u2010cyano\u20107\u2010nitroquinoxaline\u20102,3\u2010dione (CNQX, 20\u201030 microM) was depressed by trans\u2010ACPD, L\u2010AP4, or quisqualate (1\u20102 microM). 5. The response to ionophoretic application of alpha\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazole propionic acid (AMPA) was unaffected by trans\u2010ACPD or L\u2010AP4 although the simultaneously recorded EPSC was strongly depressed. In addition, paired\u2010pulse facilitation (50\u201075 ms interstimulus interval) was reversibly enhanced by trans\u2010ACPD or L\u2010AP4. These results indicate that the depression of synaptic transmission likely was mediated by a presynaptic \u2018autoreceptor\u2019. 6. The effects of trans\u2010ACPD or L\u2010AP4 on synaptic transmission decreased significantly over ages 12\u201030 days and were minimal in adult (greater than 80 days) slices. 7. The depression of synaptic transmission caused by trans\u2010ACPD or L\u2010AP4 was not altered following the induction of long\u2010term potentiation (LTP). 8. The results indicate that metabotropic glutamate receptor agonists suppress excitatory synaptic transmission in CA1 pyramidal cells by an action at a presynaptic site. This effect is developmentally regulated and is maximally expressed during the first postnatal month.<\/jats:p>","DOI":"10.1113\/jphysiol.1991.sp018901","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T17:08:35Z","timestamp":1418836115000},"page":"687-701","source":"Crossref","is-referenced-by-count":355,"title":["Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus."],"prefix":"10.1113","volume":"444","author":[{"given":"A","family":"Baskys","sequence":"first","affiliation":[]},{"given":"R C","family":"Malenka","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1991,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1991.sp018901","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1991.sp018901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T23:05:08Z","timestamp":1698015908000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1991.sp018901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1113\/jphysiol.1991.sp018901"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018901","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}