{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:10:14Z","timestamp":1764364214004},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p><jats:bold>What is the topic of this review?<\/jats:bold><\/jats:p>\n<jats:p>The present work reviews the roles of renal and intestinal dopamine and 5\u2010HT in the maintenance of fluid and electrolyte homeostasis. The role of inflammatory agents at the intestinal level that affect fluid and electrolyte homeostasis is also addressed.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p><jats:bold>What advances does it highlight?<\/jats:bold><\/jats:p>\n<jats:p>General mechanisms of epithelial cell ion transport in the gastrointestinal tract and kidney share considerable similarities, particularly with regard to basolateral Na<jats:sup>+<\/jats:sup>,K<jats:sup>+\u2010<\/jats:sup>ATPase as a driving force for the movement of numerous substrates across the cell membrane.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:label \/><jats:p>The physiological importance of the renal actions of monoamines (dopamine, noradrenaline and 5\u2010HT) mainly depends on the sources of the amines in the kidney and on their availability to activate the amine\u2010specific receptors. Dopamine and 5\u2010HT are also relatively abundant in the mucosal cell layer of the intestine, and recent evidence suggests their physiological relevance in regulating electrolyte transport. The gastrointestinal tract can be an important site for the loss of water and electrolytes, in the presence of intestinal inflammation. General mechanisms of epithelial cell ion transport in the gastrointestinal tract and kidney share considerable similarities with regard to basolateral Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>\u2010ATPase as a driving force for the movement of numerous substrates across the cell membrane. The present work reviews the roles of renal and intestinal dopamine and 5\u2010HT in the maintenance of fluid and electrolyte homeostasis. The role of inflammatory agents at the intestinal level that affect fluid and electrolyte homeostasis is also addressed.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep085284","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T10:32:46Z","timestamp":1447065166000},"page":"459-464","source":"Crossref","is-referenced-by-count":7,"title":["Amine neurotransmitters, inflammation and epithelial sodium transport"],"prefix":"10.1113","volume":"101","author":[{"given":"Patr\u00edcio","family":"Soares\u2010da\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"MedInUP \u2013 Center for Drug Discovery and Innovative Medicines University of Porto  Porto Portugal"}]},{"given":"Jos\u00e9 Miguel","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"Diogo","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"S\u00f3nia","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"MedInUP \u2013 Center for Drug Discovery and Innovative Medicines University of Porto  Porto Portugal"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"MedInUP \u2013 Center for Drug Discovery and Innovative Medicines University of Porto  Porto 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