{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:26:40Z","timestamp":1772306800028,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>New Findings<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p><jats:bold>What is the central question of this study?<\/jats:bold><\/jats:p><jats:p>Right ventricle (RV) dysfunction is highly prevalent in heart failure with preserved ejection fraction (HFpEF), nearly doubling the risk of death: what are the RV functional and structural changes in HFpEF and how does aerobic exercise impact them?<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:bold>What is the main finding and its importance?<\/jats:bold><\/jats:p><jats:p>The HFpEF ZSF1 rat model presents RV structural and functional changes mimicking the human condition. Aerobic exercise prevented the decline in <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph13105-math-0001.png\" xlink:title=\"urn:x-wiley:09580670:media:eph13105:eph13105-math-0001\"\/>, lowered surrogate markers of RV overload (e.g., higher mean and maximum systolic pressure) and improved diastolic dysfunction (e.g., end\u2010diastolic pressure and relaxation time constant). This emphasizes the importance of using exercise to manage HFpEF.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Right ventricle (RV) dysfunction is highly prevalent in heart failure with preserved ejection fraction (HFpEF) and is a marker of poor prognosis. We assessed the obese ZSF1 rat model of HFpEF to ascertain if these animals also develop RV dysfunction and evaluated whether aerobic exercise could prevent this. Obese ZSF1 rats were randomly allocated to an aerobic exercise training group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07; treadmill running, 5\u00a0days\/week, 60\u00a0min\/day, 15\u00a0m\/min for 5\u00a0weeks) or to a sedentary group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). We used lean ZSF1 rats (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) as the control group. After 5\u00a0weeks, rats were submitted to an exercise tolerance test and invasive haemodynamic evaluation, killed and samples from the RV collected for histological analysis. Obese sedentary ZSF1 rats showed lower <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/eph13105-math-0002.png\" xlink:title=\"urn:x-wiley:09580670:media:eph13105:eph13105-math-0002\"\/>, RV pressure overload (e.g., higher mean and maximum systolic pressure) and diastolic dysfunction (e.g., higher minimum and end\u2010diastolic pressure and relaxation time constant), paralleled by RV cardiomyocyte hypertrophy. Except for cardiomyocyte hypertrophy, aerobic exercise prevented these functional changes. Our data support that this model of HFpEF shows functional and structural changes in the RV that resemble the human HFpEF phenotype, reinforcing its utility to understand this pathophysiology and to adress novel therapeutic targets to manage HFpEF. In addition, we showed that aerobic exercise is cardioprotective for the RV. A deeper knowledge of the mechanisms underlying the benefits of aerobic exercise could also lead to the identification of therapeutic targets to be further explored.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep089516","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T06:48:50Z","timestamp":1634885330000},"page":"2457-2471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histological and haemodynamic characterization of right ventricle in sedentary and trained rats with heart failure with preserved ejection fraction"],"prefix":"10.1113","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-6262","authenticated-orcid":false,"given":"Maria Isilda","family":"Oliveira","sequence":"first","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Centre of Physical Activity Health and Leisure (CIAFEL) Faculty of Sport University of Porto  Porto Portugal"}]},{"given":"Sara","family":"Leite","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"},{"name":"USF Anta ACeS Gaia\/Espinho  Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-5852","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Barros","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"Andr\u00e9 P.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Department of Anesthesiology S\u00e3o Jo\u00e3o University Hospital  Porto Portugal"}]},{"given":"Cl\u00e1udia","family":"Mendes","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-2068","authenticated-orcid":false,"given":"Cristine","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Centre of Physical Activity Health and Leisure (CIAFEL) Faculty of Sport University of Porto  Porto Portugal"}]},{"given":"M\u00e1rio","family":"Santos","sequence":"additional","affiliation":[{"name":"CardioVascular Research Group Unit for Multidisciplinary Research in Biomedicine Institute of Biomedical Sciences Abel Salazar University of Porto  Porto Portugal"},{"name":"Cardiology Department Hospital de Santo Ant\u00f3nio Centro Hospitalar Universit\u00e1rio do Porto  Porto Portugal"}]},{"given":"Adelino","family":"Leite\u2010Moreira","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Center (UnIC) and Department of Surgery and Physiology Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Department of Cardiothoracic Surgery S\u00e3o Jo\u00e3o University Hospital  Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-7405","authenticated-orcid":false,"given":"Daniel","family":"Moreira\u2010Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centre of Physical Activity Health and Leisure (CIAFEL) Faculty of Sport University of Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy566.5215"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00518.2014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.06.1042"},{"key":"e_1_2_10_5_1","volume-title":"Theory and practice of histological techniques","author":"Bancroft J. 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