{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:37:53Z","timestamp":1775147873776,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Surgical aortic valve replacement (SAVR) alters the natural course of severe aortic stenosis (AS). In this study, we aimed to determine the effects of the disease on dynamic cerebral autoregulation and vasoreactivity (VR) and to assess their changes after SAVR. We recruited 23 patients diagnosed with severe AS eligible for SAVR and 15 healthy matched controls. AS patients had lower mean VR to CO<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) than controls, but dynamic cerebral autoregulation was preserved. Cerebral haemodynamics showed no significant change after SAVR. Patients with smaller baseline aortic valve areas presented with smaller low frequency phase changes after surgery (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016). Severe AS does not seem to impact dynamic cerebral autoregulation but does reduce VR to CO<jats:sub>2<\/jats:sub>. SAVR does not alter cerebral autoregulation nor vasoreactivity.<\/jats:p>","DOI":"10.1113\/ep090502","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:10:11Z","timestamp":1669011011000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study"],"prefix":"10.1113","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-9049","authenticated-orcid":false,"given":"Tiago","family":"Pedro","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  Porto Portugal"}]},{"given":"Andreia","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  Porto Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Juliana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Development Unit Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Ana Lu\u00edsa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  Porto Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Elson","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E  Porto Portugal"},{"name":"Department of Physiology and Cardiothoracic Surgery Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Gilberto","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  Porto Portugal"},{"name":"Cardiovascular Research and Development Unit Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  Porto Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health Faculty of Medicine of University of Porto  Porto Portugal"},{"name":"Cardiovascular Research and Development Unit Faculty of Medicine of University of Porto  Porto Portugal"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E.  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