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Exercise appears to somewhat counteract these effects. A terrestrial model for this is head\u2010down bedrest (HDBR), simulating gravity loss. This mirrors challenges faced by older adults in extended bedrest and space environments. The first Canadian study, backed by the Canadian Space Agency, Canadian Institutes of Health Research, and Canadian Frailty Network, aims to explore these issues. The study seeks to: (1) scrutinize the impact of 14\u2010day HDBR on physiological, psychological and neurocognitive systems, and (2) assess the benefits of exercise during HDBR. Eight teams developed distinct protocols, harmonized in three videoconferences, at the McGill University Health Center. Over 26\u00a0days, 23 participants aged 55\u201365 underwent baseline measurements, 14\u00a0days of \u22126\u00b0 HDBR, and 7\u00a0days of recovery. Half did prescribed exercise thrice daily combining resistance and endurance exercise for a total duration of 1\u00a0h. Assessments included demographics, cardiorespiratory fitness, bone health, body composition, quality of life, mental health, cognition, muscle health and biomarkers. This study has yielded some published outcomes, with more forthcoming. Findings will enrich our comprehension of HDBR effects, guiding future strategies for astronaut well\u2010being and aiding bedrest\u2010bound older adults. By outlining evidence\u2010based interventions, this research supports both space travellers and those enduring prolonged bedrest.<\/jats:p><\/jats:sec>","DOI":"10.1113\/ep091473","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T13:14:51Z","timestamp":1708348491000},"page":"812-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Myths and Methodologies: Understanding the health impact of head down bedrest for the benefit of older adults and astronauts. 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