{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:07:33Z","timestamp":1771628853889,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1981,7,16]],"date-time":"1981-07-16T00:00:00Z","timestamp":364089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Physiol"],"published-print":{"date-parts":[[1981,7,16]]},"abstract":"<jats:p>The effects of \u03b2\u2010endorphin, vasoactive intestinal polypeptide (VIP) and cholecystokinin octapeptide (CCK\u20108) on carotid chemoreceptor activity have been investigated in cats anaesthetized with pentobarbitone. Spontaneous chemoreceptor discharge was decreased by intracarotid injection of \u03b2\u2010endorphin and by low doses of VIP, whereas it was increased by CCK\u20108 and higher doses of VIP, these effects being relatively long\u2010lasting and often associated with changes in systemic blood pressure. The chemoexcitation evoked by acetylcholine and sodium cyanide was reduced during intracarotid infusion of any of the three peptides studied, and that caused by CO<jats:sub>2<\/jats:sub>\u2010saturated Locke solution was reduced by \u03b2\u2010endorphin, largely unaltered by VIP and variably affected by CCK\u20108. The inhibitory effect of \u03b2\u2010endorphin was greatly reduced by naloxone, implying that it probably involved actions at naloxone\u2010sensitive opiate receptors in the carotid body. Substance P was unable to overcome the chemoinhibitory effect of methionine enkephalin. Possible functions of polypeptides in the carotid body are discussed.<\/jats:p>","DOI":"10.1113\/expphysiol.1981.sp002556","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T17:51:09Z","timestamp":1418752269000},"page":"273-284","source":"Crossref","is-referenced-by-count":29,"title":["EFFECTS OF \u03b2\u2010ENDORPHIN, VASOACTIVE INTESTINAL POLYPEPTIDE AND CHOLECYSTOKININ OCTAPEPTIDE ON CAT CAROTID CHEMORECEPTOR ACTIVITY"],"prefix":"10.1113","volume":"66","author":[{"given":"D. S.","family":"McQueen","sequence":"first","affiliation":[]},{"given":"J. A.","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[1981,7,16]]},"container-title":["Quarterly Journal of Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fexpphysiol.1981.sp002556","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/expphysiol.1981.sp002556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T15:01:33Z","timestamp":1699455693000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/expphysiol.1981.sp002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7,16]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,7,16]]}},"alternative-id":["10.1113\/expphysiol.1981.sp002556"],"URL":"https:\/\/doi.org\/10.1113\/expphysiol.1981.sp002556","archive":["Portico"],"relation":{},"ISSN":["0144-8757"],"issn-type":[{"value":"0144-8757","type":"print"}],"subject":[],"published":{"date-parts":[[1981,7,16]]}}}