{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:18:52Z","timestamp":1772507932035,"version":"3.50.1"},"reference-count":92,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T00:00:00Z","timestamp":1492905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2015T066"],"award-info":[{"award-number":["2015T066"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2017,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart failure is one of the largest contributors to disease burden and healthcare outflow in the Western world. Despite significant progress in the treatment of heart failure, disease prognosis remains very poor, with the only curative therapy still being heart transplantation. To counteract the current situation, efforts have been made to better understand the underlying molecular pathways in the progression of cardiac disease towards heart failure, and to link the disease to novel therapeutic targets such as non\u2010coding RNAs. The non\u2010coding part of the genome has gained prominence over the last couple of decades, opening a completely new research field and establishing different non\u2010coding RNAs species as fundamental regulators of cellular functions. Not surprisingly, their dysregulation is increasingly being linked to pathology, including to cardiac disease. Pre\u2010clinically, non\u2010coding RNAs have been shown to be of great value as therapeutic targets in pathological cardiac remodelling and also as diagnostic\/prognostic biomarkers for heart failure. Therefore, it is to be expected that non\u2010coding RNA\u2010based therapeutic strategies will reach the bedside in the future and provide new and more efficient treatments for heart failure. Here, we review recent discoveries linking the function and molecular interactions of non\u2010coding RNAs with the pathophysiology of cardiac hypertrophy and heart failure.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp12298-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp273129","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T04:53:36Z","timestamp":1487912016000},"page":"4037-4050","source":"Crossref","is-referenced-by-count":24,"title":["Non\u2010coding RNAs in cardiac hypertrophy"],"prefix":"10.1113","volume":"595","author":[{"given":"Lara","family":"Ottaviani","sequence":"first","affiliation":[{"name":"Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-1187","authenticated-orcid":false,"given":"Paula A.","family":"da Costa Martins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"},{"name":"Department of Physiology and Cardiothoracic Surgery Faculty of Medicine University of Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2017,4,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.302400"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00448.2009"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161023651"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.019"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.06.008"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70577"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098119"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800188"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36154"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1582"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303252"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.008"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2011.00154.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.32"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.01.008"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305178"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.957415"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2126"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096820"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.185"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.55"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182535"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3978"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.08.009"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.879429"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.019"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt213"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138849"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2504"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.12.012"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044354"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64365"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224287"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13596"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001357"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928424"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300682"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.07.010"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000078"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942268"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309568"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.003"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1086\/426833"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.331751"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.10.008"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.249433"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057800"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00829-1"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.813576"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410622111"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.265736"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.202176"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2015.06.011"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000078"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43604"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05295"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.06.003"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.041"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608791103"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139089"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805038105"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068451"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.03.002"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003777"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.06.001"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24682"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006377"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.04.004"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07511"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.687947"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.11.003"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350117"},{"key":"e_1_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2090"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.01.011"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1003"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1475"},{"key":"e_1_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034653"},{"key":"e_1_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"e_1_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.132"},{"key":"e_1_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302476"},{"key":"e_1_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4596"},{"key":"e_1_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238522"},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22852"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003863"},{"key":"e_1_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.228437"},{"key":"e_1_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.01.002"},{"key":"e_1_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.25"},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.25"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2FJP273129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP273129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:27:15Z","timestamp":1696037235000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP273129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,23]]},"references-count":92,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,6,15]]}},"alternative-id":["10.1113\/JP273129"],"URL":"https:\/\/doi.org\/10.1113\/jp273129","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,23]]}}}