{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:54:01Z","timestamp":1775494441944,"version":"3.50.1"},"reference-count":137,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201018\u2010CE14\u20100023"],"award-info":[{"award-number":["ANR\u201018\u2010CE14\u20100023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Potassium channel subfamily K member 3 (KCNK3), encoded by the <jats:italic>KCNK3<\/jats:italic> gene, is part of the two\u2010pore domain potassium channel family, constitutively active at resting membrane potentials in excitable cells, including smooth muscle and cardiac cells. Several physiological and pharmacological mediators, such as intracellular signalling pathways, extracellular pH, hypoxia and anaesthetics, regulate KCNK3 channel function. Recent studies show that modulation of KCNK3 channel expression and function strongly influences pulmonary vascular cell and cardiomyocyte function. The altered activity of KCNK3 in pathological situations such as atrial fibrillation, pulmonary arterial hypertension and right ventricular dysfunction demonstrates the crucial role of KCNK3 in cardiovascular homeostasis. Furthermore, loss of function variants of KCNK3\u00a0have been identified in patients suffering from pulmonary arterial hypertension and atrial fibrillation. This review focuses on current knowledge of the role of the KCNK3 channel in pulmonary circulation and the heart, in healthy and pathological conditions.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tjp15654-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1113\/jp284936","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T11:45:39Z","timestamp":1689939939000},"page":"3717-3737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart"],"prefix":"10.1113","volume":"601","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2078-3271","authenticated-orcid":false,"given":"Ana\u00efs","family":"Saint\u2010Martin Willer","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay Facult\u00e9 de M\u00e9decine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999 \u2018Hypertension Pulmonaire: Physiopathologie et Innovation Th\u00e9rapeutique\u2019 H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"}]},{"given":"Joana","family":"Santos\u2010Gomes","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Centre\u2010UnIC@RISE, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-436X","authenticated-orcid":false,"given":"Rui","family":"Ad\u00e3o","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Centre\u2010UnIC@RISE, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal"},{"name":"Department of Pharmacology and Toxicology, School of Medicine Universidad Complutense de Madrid Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM) Madrid Spain"},{"name":"CIBER Enfermedades Respiratorias (Ciberes) Madrid Spain"}]},{"given":"Carmen","family":"Br\u00e1s\u2010Silva","sequence":"additional","affiliation":[{"name":"Cardiovascular R&amp;D Centre\u2010UnIC@RISE, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal"}]},{"given":"M\u00e9lanie","family":"Eyries","sequence":"additional","affiliation":[{"name":"D\u00e9partement de g\u00e9n\u00e9tique Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"},{"name":"INSERM UMRS1166, ICAN \u2013 Institute of CardioMetabolism and Nutrition Sorbonne Universit\u00e9 Paris France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-7418","authenticated-orcid":false,"given":"Francisco","family":"P\u00e9rez\u2010Vizcaino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Medicine Universidad Complutense de Madrid Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IISGM) Madrid Spain"},{"name":"CIBER Enfermedades Respiratorias (Ciberes) Madrid Spain"}]},{"given":"V\u00e9ronique","family":"Capuano","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay Facult\u00e9 de M\u00e9decine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999 \u2018Hypertension Pulmonaire: Physiopathologie et Innovation Th\u00e9rapeutique\u2019 H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"}]},{"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay Facult\u00e9 de M\u00e9decine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999 \u2018Hypertension Pulmonaire: Physiopathologie et Innovation Th\u00e9rapeutique\u2019 H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP), Service de Pneumologie et Soins Intensifs Respiratoires Centre de R\u00e9f\u00e9rence de l'Hypertension Pulmonaire, H\u00f4pital Bic\u00eatre Le Kremlin\u2010Bic\u00eatre France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-6571","authenticated-orcid":false,"given":"Fabrice","family":"Antigny","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay Facult\u00e9 de M\u00e9decine Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM UMR_S 999 \u2018Hypertension Pulmonaire: Physiopathologie et Innovation Th\u00e9rapeutique\u2019 H\u00f4pital Marie Lannelongue Le Plessis\u2010Robinson France"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303211"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020951"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37277-0"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00248"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082289"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.11.014"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0335OC"},{"issue":"9","key":"e_1_2_2_9_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006465","article-title":"The impact of heterozygous KCNK3 mutations associated with pulmonary arterial hypertension on channel function and pharmacological recovery","volume":"6","author":"Bohnen M. S.","year":"2017","journal-title":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.02.013"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-015-1689-1"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.03.005"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00475.2019"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060795"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00107.2017"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.804369"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100351"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000194289.34345.63"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277275"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277275"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000339"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331715"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002449"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-003-0409-8"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0128-x"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00739.2018"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5464"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01987-x"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.08.031"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02165-2019"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01371-2018"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.287268"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126714"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19557"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.06.002"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705691"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0454-4"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03672-4"},{"key":"e_1_2_2_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20558"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.253955"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000099883.68414.61"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.05.051"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00614.2014"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.404095"},{"key":"e_1_2_2_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033744"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601934"},{"key":"e_1_2_2_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0400-z"},{"key":"e_1_2_2_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_2_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1114174"},{"key":"e_1_2_2_52_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00745-2017"},{"key":"e_1_2_2_53_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022"},{"key":"e_1_2_2_54_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01887-2018"},{"key":"e_1_2_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.029"},{"key":"e_1_2_2_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.006974"},{"key":"e_1_2_2_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.019893"},{"key":"e_1_2_2_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.011"},{"key":"e_1_2_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60734-5"},{"key":"e_1_2_2_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/376690a0"},{"key":"e_1_2_2_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.5.H1669"},{"key":"e_1_2_2_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199904000-00024"},{"key":"e_1_2_2_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1665-1"},{"key":"e_1_2_2_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00177"},{"key":"e_1_2_2_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-002-0599-x"},{"key":"e_1_2_2_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203493"},{"key":"e_1_2_2_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy016"},{"key":"e_1_2_2_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.314793"},{"key":"e_1_2_2_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab016"},{"key":"e_1_2_2_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10091261"},{"key":"e_1_2_2_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01444-7"},{"key":"e_1_2_2_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197400"},{"key":"e_1_2_2_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-03-00868.1998"},{"key":"e_1_2_2_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2213559"},{"key":"e_1_2_2_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F793"},{"key":"e_1_2_2_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.12.014"},{"key":"e_1_2_2_77_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335757"},{"key":"e_1_2_2_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001948200"},{"key":"e_1_2_2_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211097"},{"key":"e_1_2_2_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22904"},{"key":"e_1_2_2_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07564"},{"key":"e_1_2_2_82_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206748"},{"key":"e_1_2_2_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.170050"},{"key":"e_1_2_2_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs173"},{"key":"e_1_2_2_85_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbs1404031"},{"key":"e_1_2_2_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.08.022"},{"key":"e_1_2_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.02.024"},{"key":"e_1_2_2_88_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00211811"},{"key":"e_1_2_2_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12869"},{"key":"e_1_2_2_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000219677.12988.e9"},{"key":"e_1_2_2_91_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00754-2017"},{"key":"e_1_2_2_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/8084"},{"key":"e_1_2_2_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003703"},{"key":"e_1_2_2_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.050"},{"key":"e_1_2_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104262"},{"key":"e_1_2_2_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1987.tb00674.x"},{"key":"e_1_2_2_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00100.2007"},{"key":"e_1_2_2_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.025"},{"key":"e_1_2_2_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01367"},{"key":"e_1_2_2_100_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202112989"},{"key":"e_1_2_2_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010006"},{"key":"e_1_2_2_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.002"},{"key":"e_1_2_2_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012657"},{"issue":"22","key":"e_1_2_2_104_1","first-page":"1764","article-title":"Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: Implications for patient\u2010specific antiarrhythmic drug therapy","volume":"38","author":"Schmidt C.","year":"2017","journal-title":"European Heart Journal"},{"key":"e_1_2_2_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007465"},{"key":"e_1_2_2_106_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.247692"},{"key":"e_1_2_2_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.06.020"},{"key":"e_1_2_2_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0780-9"},{"key":"e_1_2_2_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.029"},{"key":"e_1_2_2_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2009"},{"key":"e_1_2_2_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15249"},{"key":"e_1_2_2_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.895863"},{"key":"e_1_2_2_113_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_2_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-015-1779-0"},{"key":"e_1_2_2_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01185-x"},{"key":"e_1_2_2_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0242-x"},{"key":"e_1_2_2_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01319.x"},{"key":"e_1_2_2_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80903-4"},{"key":"e_1_2_2_119_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0412OC"},{"key":"e_1_2_2_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003432"},{"key":"e_1_2_2_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5407-09.2010"},{"key":"e_1_2_2_122_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.262022"},{"issue":"2","key":"e_1_2_2_123_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1165\/rcmb.2022-0245OC","article-title":"Novel loss of function KCNA5 variants in pulmonary arterial hypertension","volume":"69","author":"Vera\u2010Zambrano A.","year":"2023","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"e_1_2_2_124_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1002"},{"key":"e_1_2_2_125_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01609-2018"},{"key":"e_1_2_2_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.09.017"},{"key":"e_1_2_2_127_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01454-2021"},{"key":"e_1_2_2_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22095014"},{"key":"e_1_2_2_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab177"},{"key":"e_1_2_2_130_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015751"},{"key":"e_1_2_2_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.629421"},{"key":"e_1_2_2_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112914"},{"key":"e_1_2_2_133_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023472"},{"key":"e_1_2_2_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147396"},{"key":"e_1_2_2_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0789-9"},{"key":"e_1_2_2_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.07.628"},{"key":"e_1_2_2_137_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.117.001887"},{"key":"e_1_2_2_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0685-z"}],"updated-by":[{"DOI":"10.1113\/jp286737","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000}}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/JP284936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:20:23Z","timestamp":1693927223000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/JP284936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":137,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1113\/JP284936"],"URL":"https:\/\/doi.org\/10.1113\/jp284936","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1113\/JP286737","asserted-by":"object"}]},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"assertion":[{"value":"2023-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}