{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:28:34Z","timestamp":1790918914716,"version":"4.1.0"},"reference-count":27,"publisher":"ASME International","issue":"3","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>A pulsatile flow in vitro model of the distal end-to-side anastomosis of an arterial bypass graft was used to examine the effects that different flow ratios between the proximal outlet segment (POS) and the distal outlet segment (DOS) have on the flow patterns and the distributions of hemodynamic factors in the anastomosis. Amberlite particles were tracked by flow visualization to determine overall flow patterns and velocity measurements were made with Laser Doppler anemometry (LDA) to obtain detailed hemodynamic factors along the artery floor and the graft hood regions. These factors included wall shear stress (WSS), spatial wall shear stress gradient (WSSG), and oscillatory index (OSI). Statistical analysis was used to compare these hemodynamic factors between cases having different POS:DOS flow ratios (Case 1\u20140:100, Case 2\u201425:75, Case 3\u201450:50). The results showed that changes in POS:DOS flow ratios had a great influence on the flow patterns in the anastomosis. With an increase in proximal outlet flow, the range of location of the stagnation point along the artery floor decreased, while the extent of flow separation along the graft hood increased. The statistical results showed that there were significant differences p&lt;0.05 for the mean WSS between cases along the graft hood, but no significant differences were detected along the artery floor. There were no significant differences for the spatial WSSG along both the artery floor and the graft hood. However, there were significant differences p&lt;0.05 in the mean OSI between Cases 1 and 2 and between Cases 1 and 3 both along the artery floor and along the graft hood. Comparing these mechanical factors with histological findings of intimal hyperplasia formation obtained by previous canine studies, the results of the statistical analysis suggest that regions exposed to a combination of low mean WSS and high OSI may be most prone to the formation of intimal hyperplasia.<\/jats:p>","DOI":"10.1115\/1.1372323","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:02:17Z","timestamp":1027760537000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":21,"title":["Hemodynamic Factors at the Distal End-to-Side Anastomosis of a Bypass Graft With Different POS:DOS Flow Ratios"],"prefix":"10.1115","volume":"123","author":[{"given":"Xue-Mei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, The University of Akron, Akron, OH\u200944325-0302"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley E.","family":"Rittgers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The University of Akron, Akron, OH\u200944325-0302"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2000,12,13]]},"reference":[{"key":"2019100607512617100_r1","unstructured":"Echave, V., Koornick, A. 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