{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:09:50Z","timestamp":1790233790779,"version":"4.1.0"},"reference-count":37,"publisher":"ASME International","issue":"4","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>The technique of large-eddy simulation (LES) has been applied to the study of pulsatile flow through a modeled arterial stenosis. A simple stenosis model has been used that consists of a one-sided 50 percent semicircular constriction in a planar channel. The inlet volume flux is varied sinusoidally in time in a manner similar to the laminar flow simulations of Tutty (1992). LES is used to compute flow at a peak Reynolds number of 2000 and a Strouhal number of 0.024. At this Reynolds number, the flow downstream of the stenosis transitions to turbulence and exhibits all the classic features of post-stenotic flow as described by Khalifa and Giddens (1981) and Lieber and Giddens (1990). These include the periodic shedding of shear layer vortices and transition to turbulence downstream of the stenosis. Computed frequency spectra indicate that the vortex shedding occurs at a distinct high frequency, and the potential implication of this for noninvasive diagnosis of arterial stenoses is discussed. A variety of statistics have been also extracted and a number of other physical features of the flow are described in order to demonstrate the usefulness of LES for the study of post-stenotic flows.<\/jats:p>","DOI":"10.1115\/1.1385840","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:04:46Z","timestamp":1027760686000},"page":"325-332","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":76,"title":["Application of Large-Eddy Simulation to the Study of Pulsatile Flow in a Modeled Arterial Stenosis"],"prefix":"10.1115","volume":"123","author":[{"given":"R.","family":"Mittal","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Florida, Gainesville, FL\u200932611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Florida, Gainesville, FL\u200932611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Udaykumar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Iowa, Iowa City, IA\u200952242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2001,3,26]]},"reference":[{"key":"2019100610503988100_r1","doi-asserted-by":"crossref","unstructured":"Fung, Y. C., 1997, Biomechanics: Circulation, 2nd ed., Springer-Verlag, New York.","DOI":"10.1097\/00024382-199802000-00018"},{"key":"2019100610503988100_r2","doi-asserted-by":"crossref","unstructured":"Pedley, T. J., 1980, The Fluid Mechanics of Large Blood Vessels, Cambridge University Press, Cambridge.","DOI":"10.1017\/CBO9780511896996"},{"key":"2019100610503988100_r3","unstructured":"White, F. 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