{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:47:50Z","timestamp":1791344870620,"version":"4.3.1"},"reference-count":37,"publisher":"ASME International","issue":"6","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:p>A finite-length liquid plug may be present in an airway due to disease, airway closure, or by direct instillation for medical therapy. Air forced by ventilation propagates the plug through the airways, where it deposits fluid onto the airway walls. The plug may encounter single or bifurcating airways, an airway surface liquid, and other liquid plugs in nearby airways. In order to understand how these flow situations influence plug transport, benchtop experiments are performed for liquid plug flow in: Case (i) straight dry tubes, Case (ii) straight pre-wetted tubes, Case (iii) bifurcating dry tubes, and Case (iv) bifurcating tubes with a liquid blockage in one daughter. Data are obtained for the trailing film thickness and plug splitting ratio as a function of capillary number and plug volumes. For Case (i), the finite length plug in a dry tube has similar behavior to a semi-infinite plug. For Case (ii), the trailing film thickness is dependent upon the plug capillary number (Ca) and not the precursor film thickness, although the shortening or lengthening of the liquid plug is influenced by the precursor film. For Case (iii), the plug splits evenly between the two daughters and the deposited film thickness depends on the local plug Ca, except for a small discrepancy that may be due to an entrance effect or from curvature of the tubes. For Case (iv), a plug passing from the parent to daughters will deliver more liquid to the unblocked daughter (nearly double, consistently) and then the plug will then travel at greater Ca in the unblocked daughter as the blocked. The flow asymmetry is enhanced for a larger blockage volume and diminished for a larger parent plug volume and parent-Ca.<\/jats:p>","DOI":"10.1115\/1.1406949","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:03:10Z","timestamp":1027746190000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":47,"title":["Liquid Plug Flow in Straight and Bifurcating Tubes"],"prefix":"10.1115","volume":"123","author":[{"given":"K. J.","family":"Cassidy","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gavriely","sequence":"additional","affiliation":[{"name":"Department of Physiology, Technion\u2014Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Grotberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2001,6,7]]},"reference":[{"key":"2019100600271190400_r1","doi-asserted-by":"crossref","unstructured":"Long, W., Thompson, T., Sundell, H., Schumacher, R., Volberg, F., and Guthrie, R., 1991, \u201cEffects of Two Rescue Doses of a Synthetic Surfactant on Mortality Rate and Survival Without Bronchopulmonary Dysplasia in 700- to 1350-Gram Infants With Respiratory Distress Syndrome.\u201d The American Exosurf Neonatal Study Group I. J. Pediatr. (St. Louis), 118, pp. 595\u2013605.","DOI":"10.1016\/S0022-3476(05)83388-8"},{"key":"2019100600271190400_r2","doi-asserted-by":"crossref","unstructured":"Yu, J., and Chien, Y. W., 1997, \u201cPulmonary Drug Delivery: Physiologic and Mechanistic Aspects,\u201d Crit. Rev. Ther. 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