{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:53:10Z","timestamp":1790423590546,"version":"4.1.0"},"reference-count":35,"publisher":"ASME International","issue":"1","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,2,1]]},"abstract":"<jats:p>The cause of cavitation in mechanical heart valves is investigated with Medtronic Hall tilting disk valves in an in vitro flow system simulating the closing event in the mitral position. Recordings of pressure wave forms and photographs in the vicinity of the inflow surface of the valve are attempted under controlled transvalvular loading rates averaged during valve closing period. The results revealed presence of a local flow field with a very high velocity around the seat stop of mechanical heart valves that could induce pressure reduction below liquid vapor pressure and a cloud of cavitation bubbles. The analysis of the results indicates that the \u201cfluid squeezing\u201d between the stop and occluder as the main cause of cavitation in Medtronic Hall valves. The threshold loading rate for cavitation initiation around the stop was found to be very low (300 and 400 mmHg\/s; half the predicted normal human loading rate that was estimated to be 750 mmHg\/s) because even a mild impact created a high speed local flow field on the occluder surface that could induce pressure reduction below vapor pressure. The present study suggests that mechanical heart valves with stops at the edge of major orifice region are more vulnerable to cavitation, and hence, have higher potential for damage on valve components and formed elements in blood.<\/jats:p>","DOI":"10.1115\/1.2795951","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T20:37:32Z","timestamp":1203626252000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":30,"title":["Cavitation Dynamics of Medtronic Hall Mechanical Heart Valve Prosthesis: Fluid Squeezing Effect"],"prefix":"10.1115","volume":"118","author":[{"given":"C. S.","family":"Lee","sequence":"first","affiliation":[{"name":"University of Iowa, Iowa City, IZ 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. B.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Departments of Biomedical and Mechanical Engineering, University of Iowa, Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. D.","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"2019100604031725900_r1","doi-asserted-by":"crossref","unstructured":"Bluestein D. , EinavS., and HwangN. H. C., 1994, \u201cA Squeeze Flow Phenomenon at the Closing of a Bileaflet Mechanical Heart Valve Prosthesis,\u201d J. Biomechanics, Vol. 27, pp. 1369\u20131378.","DOI":"10.1016\/0021-9290(94)90046-9"},{"key":"2019100604031725900_r2","unstructured":"Chandran, K. B., 1988, \u201cHeart Valve Prostheses: in vitro flow dynamics,\u201d in Encyclopedia of Medical Devices and Instrumentation John G., Webster, ed., Wiley, New York, 3rd ed., pp. 1475\u20131483."},{"key":"2019100604031725900_r3","doi-asserted-by":"crossref","unstructured":"Chandran K. B. , SchoephoersterR., and DellspergerK. C., 1989, \u201cEffect of prosthetic mitral valve geometry and orientation on flow dynamics in a model human left ventricle,\u201d J. Biomechanics, Vol. 22, pp. 51\u201365.","DOI":"10.1016\/0021-9290(89)90184-X"},{"key":"2019100604031725900_r4","unstructured":"Chandran K. B. , LeeC. S., and ChenL. D., 1994, \u201cPressure field in the vicinity of mechanical valve occluders at the instant of valve closure: Correlation with cavitation initiation,\u201d J. Heart Valve Disease, Vol. 3 (Suppl. 1), pp. S65\u2013S76S65\u2013S76."},{"key":"2019100604031725900_r5","doi-asserted-by":"crossref","unstructured":"Cheon, G. J., and Chandran, K. B., 1994, \u201cTransient behavior analysis of a mechanical monoleaflet heart valve prosthesis in the closing phase,\u201d ASME JOURNAL OF BIOMECHANICAL ENGINEERING (in press).","DOI":"10.1115\/1.2895796"},{"key":"2019100604031725900_r6","unstructured":"Dimitri W. R. , and WilliamsB. T., 1990, \u201cFracture of the Duromedics Mitral Valve Housing with Leaflet Escape,\u201d J. of Cardiovascular Surg., Vol. 31(1), pp. 41\u201346."},{"key":"2019100604031725900_r7","unstructured":"Deuvaert F. E. , DevriendtJ., and MassautJ., 1989, \u201cLeaflet escape of a mitral Duromedics prosthesis (case report), Acta Chir Belgium, Vol. 89, pp. 15\u201318."},{"key":"2019100604031725900_r8","unstructured":"Garrison L. A. , LamsonT. C., DeutschS., GeselowitzD. B., GaumondR. P., and TarbellJ. M., 1994, \u201cAn in-vitro investigation of prosthetic heart valve cavitation in blood,\u201d J. 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