{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:23:56Z","timestamp":1696969436191},"reference-count":27,"publisher":"ASME International","issue":"3","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>In order to clarify the gas transport process in high-frequency oscillation, we measured the axial velocity profile and the axial effective diffusivity in a single asymmetric bifurcating tube, based on the Horsfield airway model, with sinusoidally oscillatory flow. The axial velocity profiles were measured using a laser-Doppler velocimeter, and the effective diffusivities were evaluated using a simple bolus injection method. The axial velocity profile was found to be nonuniform, promoting axial gas dispersion by the spread of the concentration profile and lateral mixing. The geometric asymmetry of the bifurcation was responsible for the difference in gas transport between the main bronchi. The axial gas transport in the left main bronchus was 2.3 times as large as that of the straight tube, whereas the gas transport in the right main bronchus was slightly larger than that of the straight tube. Thus localized variation in gas transport characterized the heterogeneous respiratory function of the lung.<\/jats:p>","DOI":"10.1115\/1.2796095","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T20:48:52Z","timestamp":1203626932000},"page":"309-316","update-policy":"http:\/\/dx.doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":11,"title":["Gas Dispersion in a Model Pulmonary Bifurcation During Oscillatory Flow"],"prefix":"10.1115","volume":"119","author":[{"given":"M.","family":"Nishida","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, & Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Inaba","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, & Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tanishita","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, & Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2019100604374725500_r1","doi-asserted-by":"crossref","unstructured":"Bohn\n              D. J.\n            , MiyasakaK., MarchakB. E., ThompsonW. K., FroeseA. B., and BryanA. C., \u201cVentilation by high frequency oscillation,\u201d J. Appl. Physiol. Respirat. Environ. Exercise Physiol., Vol. 48, 1980, pp. 710\u2013716.","DOI":"10.1152\/jappl.1980.48.4.710"},{"key":"2019100604374725500_r2","unstructured":"Kamm\n              R. D.\n            , SlutskyA. S., and DrazenJ. M., \u201cHigh-frequency ventilation,\u201d CRC Reviews in Biomed. Eng., Vol. 9, 1984, pp. 347\u2013379."},{"key":"2019100604374725500_r3","doi-asserted-by":"crossref","unstructured":"Grotberg\n              J. B.\n            \n          , \u201cPulmonary flow and transport phenomena,\u201d Annu. Rev. Fluid Mech., Vol. 26, 1994, pp. 529\u2013571.","DOI":"10.1146\/annurev.fl.26.010194.002525"},{"key":"2019100604374725500_r4","doi-asserted-by":"crossref","unstructured":"Tarbell\n              J. M.\n            , UltmanJ. S., and DurlofskyL., \u201cOscillatory convective dispersion in a branching tube network,\u201d ASME JOURNAL OF BIOMECHANICAL ENGINEERING, Vol. 104, 1982, pp. 338\u2013342.","DOI":"10.1115\/1.3138369"},{"key":"2019100604374725500_r5","doi-asserted-by":"crossref","unstructured":"Kamm\n              R. D.\n            , CollinsJ., WhangJ., SlutskyA. S., and GreinerM., \u201cGas transport during oscillatory flow in a network of branching tubes,\u201d ASME JOURNAL OF BIOMECHANICAL ENGINEERING, Vol. 106, 1984, pp. 315\u2013320.","DOI":"10.1115\/1.3138500"},{"key":"2019100604374725500_r6","doi-asserted-by":"crossref","unstructured":"Paloski\n              W. H.\n            , SlosbergR. B., and KammR. D., \u201cEffects of gas properties and waveform asymmetry on gas transport in a branching tube network,\u201d J. Appl. Physiol., Vol. 63, 1987, pp. 892\u2013902.","DOI":"10.1152\/jappl.1987.62.3.892"},{"key":"2019100604374725500_r7","doi-asserted-by":"crossref","unstructured":"Taylor\n              G. I.\n            \n          , \u201cDispersion of soluble matter in solvent flowing slowly through a pipe,\u201d Proc. R. Soc. Lond., Vol. A219, 1953, pp. 186\u2013203.","DOI":"10.1098\/rspa.1953.0139"},{"key":"2019100604374725500_r8","doi-asserted-by":"crossref","unstructured":"Watson\n              E. J.\n            \n          , \u201cDiffusion in oscillatory pipe flow,\u201d J. Fluid Mech., Vol. 133, 1983, pp. 233\u2013244.","DOI":"10.1017\/S0022112083001883"},{"key":"2019100604374725500_r9","doi-asserted-by":"crossref","unstructured":"Joshi\n              C. H.\n            , KammR. D., DragenJ. M., and SlutskyA. S., \u201cAn experiment study of gas exchange in laminar oscillatory flow,\u201d J. 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Engng Sci., Vol. 31, 1976, pp. 215\u2013218.","DOI":"10.1016\/0009-2509(76)85059-2"},{"key":"2019100604374725500_r13","doi-asserted-by":"crossref","unstructured":"Johnson\n              M.\n            , and KammR. D., \u201cNumerical studies of steady flow dispersion at low Dean number in gently curving tube,\u201d J. Fluid Mech., Vol. 172, 1986, pp. 329\u2013345.","DOI":"10.1017\/S0022112086001763"},{"key":"2019100604374725500_r14","doi-asserted-by":"crossref","unstructured":"Eckmann\n              D. M.\n            , and GrotbergJ. B., \u201cOscillatory flow and mass transport in a curved pipe,\u201d J. Fluid Mech., Vol. 188, 1988, pp. 509\u2013527.","DOI":"10.1017\/S0022112088000825"},{"key":"2019100604374725500_r15","doi-asserted-by":"crossref","unstructured":"Sharp\n              M. K.\n            , KammR. D., ShapiroA. H., KimmelE., and KarniadakisG. E., \u201cDispersion in a curved tube during oscillatory flow,\u201d J. 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D.\n            \n          , \u201cToward improved methods of high frequency ventilation: a study of gas transport mechanisms,\u201d Acta Anaesthesiol Scand, suppl. 90, 1989, pp. 51\u201357.","DOI":"10.1111\/j.1399-6576.1989.tb03004.x"},{"key":"2019100604374725500_r25","doi-asserted-by":"crossref","unstructured":"Naruse\n              T.\n            , NishinaY., KugenumaS., and TanishitaK., \u201cDeveloping oscillatory flow in a strongly curved tube,\u201d Trans. Jpn. Soc. Mech. Eng., ser. B, Vol. 56-529, 1990, pp. 2562\u20132569.","DOI":"10.1299\/kikaib.56.2562"},{"key":"2019100604374725500_r26","doi-asserted-by":"crossref","unstructured":"Hino\n              M.\n            , SawamotoM., and TakasuS., \u201cExperiments on transition to turbulence in an oscillatory pipe flow,\u201d J. 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