{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:46:46Z","timestamp":1769168806992,"version":"3.49.0"},"reference-count":28,"publisher":"ASME International","issue":"3","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>Severe occlusion of graft\u2013artery junctions due to restenosis, e.g., excessive tissue overgrowth and renewed plaque formation, may occur within a few months or years after bypass surgery. Our hypothesis is that nonuniform hemodynamics, represented by large sustained wall shear stress gradients, trigger abnormal biological processes leading to rapid restenosis and hence early graft failure. In turn, this problem may be significantly mitigated by designing graft-artery bypass configurations for which the wall shear stress gradient (WSSG) is approximately zero and hence nearly uniform hemodynamics are achieved. Focusing on the distal end of several femoral artery bypass junctions, a validated finite volume code has been used to compute the transient three-dimensional velocity vector fields and its first and second surface derivatives in order to test the idea. Specifically, it is shown that the Taylor patch, which generates higher patency rates than standard end-to-side anastomoses, exhibits lower WSSG levels than standard configurations, and that further geometric design improvements reduce the WSSG in magnitude and local extent even more.<\/jats:p>","DOI":"10.1115\/1.2796099","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T15:37:32Z","timestamp":1203608252000},"page":"343-348","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":37,"title":["Hemodynamic Simulations and Computer-Aided Designs of Graft-Artery Junctions"],"prefix":"10.1115","volume":"119","author":[{"given":"M.","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kleinstreuer","sequence":"additional","affiliation":[{"name":"Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Archie","sequence":"additional","affiliation":[{"name":"Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2019100603242673100_r1","unstructured":"Anonymous, \u201cCFDS-FLOW3D Manuals for Version 3.2,\u201d AEA-CFDS, Pittsburgh, PA, 1991."},{"key":"2019100603242673100_r2","doi-asserted-by":"crossref","unstructured":"Barbee\n              K. A.\n            , DaviesP. F., and LalR., \u201cShear stress-induced reorganization of the surface topography of living endothelial cell imaged by atomic force microscopy,\u201d Circ. Res., 1994, Vol. 74, pp. 163\u2013171.","DOI":"10.1161\/01.RES.74.1.163"},{"key":"2019100603242673100_r3","unstructured":"Chervu\n              A.\n            , and MooreW. 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