{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:28:59Z","timestamp":1790918939714,"version":"4.1.0"},"reference-count":39,"publisher":"ASME International","issue":"6","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>Endovascular coiling is an acceptable treatment of intracranial aneurysms, yet long term follow-ups suggest that endovascular coiling fails to achieve complete aneurysm occlusions particularly in wide-neck and giant aneurysms. Placing of a stentlike device across the aneurysm neck may be sufficient to occlude the aneurysm by promoting intra-aneurysmal thrombosis; however, conclusive evidence of its efficacy is still lacking. In this study, we investigate in vitro the efficacy of custom designed flow divertors that will be subsequently implanted in a large cohort of animals. The aim of this study is to provide a detailed database against which in vivo results can be analyzed. Six custom designed flow divertors were fabricated and tested in vitro. The design matrix included three different porosities (75%, 70%, and 65%). For each porosity, there were two divertors with one having a nominal pore density double than that of the other. To quantify efficacy, the divertors were implanted in a compliant elastomeric model of an elastase-induced aneurysm model in rabbit and intra-aneurysmal flow changes were evaluated by particle image velocimetry (PIV). PIV results indicate a marked reduction in intra-aneurysmal flow activity after divertor implantation in the innominate artery across the aneurysm neck. The mean hydrodynamic circulation after divertor implantation was reduced to 14% or less of the mean circulation in the control and the mean intra-aneurysmal kinetic energy was reduced to 29% or less of its value in the control. The intra-aneurysmal wall shear rate in this model is low and implantation of the flow divertor did not change the wall shear rate magnitude appreciably. This in vitro experiment evaluates the characteristics of local flow phenomena such as hydrodynamic circulation, kinetic energy, wall shear rate, perforator flow, and changes of these parameters as a result of implantation of stentlike flow divertors in an elastomeric replica of elastase-induced saccular aneurysm model in rabbit. These initial findings offer a database for evaluation of in vivo implantations of such devices in the animal model and help in further development of cerebral aneurysm bypass devices.<\/jats:p>","DOI":"10.1115\/1.2800787","type":"journal-article","created":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T23:20:52Z","timestamp":1197069652000},"page":"863-872","update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":57,"title":["In Vitro Evaluation of Flow Divertors in an Elastase-Induced Saccular Aneurysm Model in Rabbit"],"prefix":"10.1115","volume":"129","author":[{"given":"Jaehoon","family":"Seong","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K.","family":"Wakhloo","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue, Worchester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch B.","family":"Lieber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, and Department of Radiology, University of Miami, 1251 Memorial Drive, Coral Gables, FL 33146"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2007,3,7]]},"reference":[{"key":"2019100410582848900_c1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1474-4422(03)00661-6","article-title":"Unruptured Intracranial Aneurysms: Benign Curiosity or Ticking Bomb?","volume":"3","author":"Mitchell","journal-title":"Lancet Neurol.","ISSN":"https:\/\/id.crossref.org\/issn\/1474-4422","issn-type":"print"},{"key":"2019100410582848900_c2","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1161\/01.STR.0000031928.71695.A9","article-title":"Guglielmi Detachable Coil Embolization of Posterior Circulation Aneurysms: A Systematic Review of the Literature","volume":"33","author":"Lozier","journal-title":"Stroke","ISSN":"https:\/\/id.crossref.org\/issn\/0039-2499","issn-type":"print"},{"key":"2019100410582848900_c3","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of Neurosurgical Clipping Versus Endovascular Coiling in 2143 Patients With Ruptured Intracranial Aneurysms: A Randomised Trial","volume":"360","author":"International Subarachnoid Aneurysm Trial","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"2019100410582848900_c4","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1258\/jrsm.96.11.540","article-title":"Intracranial Aneurysm Surgery and Its Future","volume":"96","author":"Maurice-Williams","journal-title":"J. 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P., Morino, T., Nomura, K., Tanishita, K., and Vi\u00f1uela, F., 2003, \u201cIn Vitro Measurement of Fluid-Induced Wall Shear Stress in Unruptured Cerebral Aneurysms Harboring Blebs,\u201d Stroke, 34, pp. 187\u2013192.","DOI":"10.1161\/01.STR.0000046456.26587.8B"},{"key":"2019100410582848900_c37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF02427891","article-title":"Pulsatile Flows in a Lateral Aneurysm Anchored on a Stented and Curved Parent Vessel","volume":"44","author":"Liou","journal-title":"Exp. Mech.","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4851","issn-type":"print"},{"issue":"4","key":"2019100410582848900_c38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3171\/jns.1999.91.4.0538","article-title":"Efficacy and Current Limitations of Intravascular Stents for Intracranial Internal Carotid, Vertebral, and Basilar Artery Aneurysms","volume":"91","author":"Lanzino","journal-title":"J. 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