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The increase in intracellular calcium was blocked using a variety of calcium channel blocking agents, including verapamil, nifedipine, and nickel. Treatment with the channel blockers was also effective in either decreasing or eliminating cell death despite the presence of lethal doses of photosensitizer and irradiation. These results show that intracellular calcium rises prior to plasma membrane lysis, and that this early rise in intracellular calcium is necessary for membrane rupture.<\/jats:p>","DOI":"10.1115\/1.2834746","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T20:48:52Z","timestamp":1203626932000},"page":"570-578","update-policy":"http:\/\/dx.doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":4,"title":["Intracellular Calcium Dynamics During Photolysis"],"prefix":"10.1115","volume":"120","author":[{"given":"N. 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