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The motion of the valve leaflets are calculated through a strongly coupled FSI algorithm implemented in conjunction with the Aitken convergence acceleration technique. We perform simulations for three valve orientations, which differ from each other by 45 deg and compare the results in terms of leaflet motion and flow field. We show that the valve implanted symmetrically relative to the symmetry plane of the ascending aorta curvature exhibits the smallest overall asymmetry in the motion of its two leaflets and lowest rebound during closure. Consequently, we hypothesize that this orientation is beneficial to reduce the chance of intermittent regurgitation. Furthermore, we find that the valve orientation does not significantly affect the shear stress distribution in the aortic lumen, which is in agreement with previous studies.<\/jats:p>","DOI":"10.1115\/1.4002491","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T22:01:08Z","timestamp":1283464868000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":50,"title":["The Effect of Implantation Orientation of a Bileaflet Mechanical Heart Valve on Kinematics and Hemodynamics in an Anatomic Aorta"],"prefix":"10.1115","volume":"132","author":[{"given":"Iman","family":"Borazjani","sequence":"first","affiliation":[{"name":"St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Sotiropoulos","sequence":"additional","affiliation":[{"name":"St. Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55414"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"issue":"6","key":"2019100512205741200_c1","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/0049-3848(78)90232-3","article-title":"Platelet Response to Shear Stress: Changes in Serotonin Uptake, Serotonin Release, and ADP Induced Aggregation","volume":"13","author":"Anderson","journal-title":"Thromb. 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