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We demonstrate the use of this methodology by determining the minimal rheological arrangement, constitutive relationships, and model parameters for the structural response of various soft tissues, including ex vivo perfused porcine liver in indentation, ex vivo porcine brain cortical tissue in indentation, and ex vivo human cervical tissue in unconfined compression. Our results indicate that the identified rheological configurations provide good agreement with experimental data, including multiple constant strain rate load\/unload tests and stress relaxation tests. Our experience suggests that the described modeling framework is an efficient tool for exploring a wide array of constitutive relationships and rheological arrangements, which can subsequently serve as a basis for 3D constitutive model development and finite-element implementations. The proposed approach can also be employed as a self-contained tool to obtain simplified 1D phenomenological models of the structural response of biological tissue to single-axis manipulations for applications in haptic technologies.<\/jats:p>","DOI":"10.1115\/1.4003620","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T22:05:14Z","timestamp":1300226714000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":16,"title":["Identifying a Minimal Rheological Configuration: A Tool for Effective and Efficient Constitutive Modeling of Soft Tissues"],"prefix":"10.1115","volume":"133","author":[{"given":"Petr","family":"Jordan","sequence":"first","affiliation":[{"name":"Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Kerdok","sequence":"additional","affiliation":[{"name":"Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Howe","sequence":"additional","affiliation":[{"name":"Harvard School of Engineering and Applied Sciences, Cambridge, MA 02138; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Socrate","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"2019100411200234800_c1","volume-title":"Viscoelastic Properties of Polymers","author":"Ferry"},{"key":"2019100411200234800_c2","volume-title":"Biomechanics: Mechanical Properties of Living Tissues","author":"Fung","edition":"2nd ed."},{"key":"2019100411200234800_c3","doi-asserted-by":"crossref","volume-title":"Mechanical Properties of Solid Polymers","author":"Ward","DOI":"10.1002\/9781119967125"},{"key":"2019100411200234800_c4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1109\/58.484478","article-title":"Young\u2019s Modulus Measurements of Soft Tissues With Application to Elasticity Imaging","volume":"43","author":"Chen","journal-title":"IEEE Trans. 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