{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:25Z","timestamp":1753879165797,"version":"3.41.2"},"reference-count":47,"publisher":"ASME International","issue":"4","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>The driving force that causes enlargement of the ventricles remains unclear in case of normal pressure hydrocephalus (NPH). Both healthy and NPH brain conditions are characterized by a low transparenchymal pressure drop, typically 1 mm Hg. The present paper proposes an analytical model for normal and NPH brains using Darcy\u2019s and Biot\u2019s equations and simplifying the brain geometry to a hollow sphere with an internal and external radius. Self-consistent solutions for the large deformation problem that is associated with large ventricle dilation are presented and the notion of equilibrium or stable ventricle position is highlighted for both healthy and NPH conditions. The influence of different biomechanical parameters on the stable ventricle geometry is assessed and it is shown that both CSF seepage through the ependyma and parenchymal permeability play a key role. Although very simple, the present model is able to predict the onset and development of NPH conditions as a deviation from healthy conditions.<\/jats:p>","DOI":"10.1115\/1.4006466","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T22:17:40Z","timestamp":1333059460000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":11,"title":["Ventricle Equilibrium Position in Healthy and Normal Pressure Hydrocephalus Brains Using an Analytical Model"],"prefix":"10.1115","volume":"134","author":[{"given":"K.","family":"Shahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Drezet","sequence":"additional","affiliation":[{"name":"LSMX,Ecole Polytechnique,F\u00e9d\u00e9rale de Lausanne, Station 12, CH-1015, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryn A.","family":"Martin","sequence":"additional","affiliation":[{"name":"LHTC,Ecole Polytechnique,F\u00e9d\u00e9rale de Lausanne, Station 17, CH-1015, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Momjian","sequence":"additional","affiliation":[{"name":"University Hospitals of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 41211 Gen\u00e8ve 14, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"issue":"1","key":"2019100414283362900_c1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3171%2Fjns.1987.67.1.0088","article-title":"Progressive Ventricular Enlargement in Cats in the Absence of Transmantle Pressure Gradients","volume":"67","author":"Shapiro","journal-title":"J. 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